iGMDRD408


Canonical SMILES: CCN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(N3)N=CN=C4NC(C)C5=CC=CC=C5

InChI: InChI=1S/C27H32N6/c1-3-32-13-15-33(16-14-32)18-21-9-11-23(12-10-21)25-17-24-26(28-19-29-27(24)31-25)30-20(2)22-7-5-4-6-8-22/h4-12,17,19-20H,3,13-16,18H2,1-2H3,(H2,28,29,30,31)/t20-/m1/s1

InChI Key: OONFNUWBHFSNBT-HXUWFJFHSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameAEE788
Pubchem CID10297000
DRUGBANK IDDB12558
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Lung Cancer model num: 1

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
1956 EGFR 1
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Gene in drug-gene network: Network Plot

Models in AEE788

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
SNV(EGFR T790M) gene 18227510 LUNG Lung Cancer AEE788 resistance or unresponsive in vivo
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