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iGMDRD240

Canonical SMILES: CN1CCC(CC1)COC2=C(C=C3C(=C2)N=CN=C3NC4=C(C=C(C=C4)Br)F)OC

InChI: InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27)

InChI Key: UHTHHESEBZOYNR-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Vandetanib	CHEMBL24828 CHEMBL533849	3081360	DB05294	Alone	Small Molecule

Drug Class:

Antineoplastic Agents Antineoplastic and Immunomodulating Agents BCRP/ABCG2 Inhibitors Heterocyclic Compounds Heterocyclic Compounds, 1-Ring Heterocyclic Compounds, 2-Ring Highest Risk QTc-Prolonging Agents Kinase Inhibitor Protein Kinase Inhibitors QTc Prolonging Agents

Drug Targets:

Flt3 C-KIT FLT4 KDR VEGFA (P15692)EGFR (P00533)PTK6 (Q13882)TEK (Q02763)RET (P07949)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
10413	YAP1	1
1956	EGFR	1
5979	RET	10
208	AKT2	1
25	ABL1	1

Gene in drug-gene network: Network Plot

Models in Vandetanib

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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.