iGMDRD492

Canonical SMILES: C1=CC2=C(C=C1Cl)C(=O)C3=NC(=C(N=C23)C#N)C#N

InChI: InChI=1S/C13H3ClN4O/c14-6-1-2-7-8(3-6)13(19)12-11(7)17-9(4-15)10(5-16)18-12/h1-3H

InChI Key: BIGPXXAUSQLTQR-UHFFFAOYSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameHBX-41108
Pubchem CID16065800
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 4

Drug-gene pathway enrichments

3reactome: Signaling by Receptor Tyrosine Kinases3reactome: Disease3reactome: Signal Transduction2kegg: Calcium signaling pathway - Homo sapiens (human)2reactome: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling2reactome: MAPK1/MAPK3 signaling2reactome: MAPK family signaling cascades2kegg: Human papillomavirus infection - Homo sapiens (human)2reactome: RAF/MAP kinase cascade2kegg: MicroRNAs in cancer - Homo sapiens (human)

Drug-gene GO enrichments

7MF: protein tyrosine kinase activity6BP: positive regulation of ERK1 and ERK2 cascade4BP: negative regulation of apoptotic process4CC: cytoplasm4MF: epidermal growth factor-activated receptor activity3BP: positive regulation of smooth muscle cell proliferation3BP: positive regulation of cell proliferation3CC: receptor complex3MF: platelet-derived growth factor binding3MF: transmembrane receptor protein tyrosine kinase activity

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
5159 PDGFRB 1
54658 UGT1A1 1
1956 EGFR 1
Showing 1 to 3 of 3 rows

Gene in drug-gene network: Network Plot

quinoclaminequinoclamineISX-9ISX-9BIX01294BIX01294ABT737ABT737Merck60Merck60BRD6368BRD6368leucascandrolide Aleucascandrolide AavrainvillamideavrainvillamideNPC26NPC26piperlonguminepiperlongumineBRD7137BRD7137PAC-1PAC-1PDGFRBPDGFRBtipifarnib-P2tipifarnib-P2GefitnibGefitnibcetuximabcetuximabGW-405833GW-405833NSC95397NSC95397DC-45-A2DC-45-A2DacomitinibDacomitinibAfatnibAfatnibirreversible EGFR TKIsirreversible EGFR TKIsErlotinibErlotinibPanitumumabPanitumumabEGFR TKIsEGFR TKIsOsimertinibOsimertinibHSP90 inhibitorsHSP90 inhibitorspevonedistatpevonedistatMEK inhibitors (alone or in combination)MEK inhibitors (alone or in combination)nutlin 3nutlin 3EGFREGFRSMER3SMER3BIRB-796BIRB-796importazoleimportazolePL.DIPL.DIAM-580AM-580NilotinibNilotinibfingolimodfingolimodBelinostatBelinostaterastinerastinIrinotecanIrinotecanUGT1A1UGT1A1HBX-41108HBX-41108

Models in HBX-41108

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
EXP(EGFR) protein MCLP undefined PANCAN HBX.41108 sensitivity in vitro
EXP(TRANSGLUTAMINASE) protein MCLP undefined PANCAN HBX.41108 sensitivity in vitro
EXP(PDGFRB) protein MCLP undefined PANCAN HBX.41108 resistance in vitro
EXP(UGT1A) protein MCLP undefined PANCAN HBX.41108 sensitivity in vitro
Showing 1 to 4 of 4 rows

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