iGMDRD695

Canonical SMILES: C1=CC=C(C=C1)C2=NN3C=CC=CC3=C2C4=NN=C5C(=C4)C(=NN5)N

InChI: InChI=1S/C18H13N7/c19-17-12-10-13(20-22-18(12)23-21-17)15-14-8-4-5-9-25(14)24-16(15)11-6-2-1-3-7-11/h1-10H,(H3,19,21,22,23)

InChI Key: XVECMUKVOMUNLE-UHFFFAOYSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameFR-180204
Pubchem CID53338800
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

ERK

Drug Pathways:

ERK MAPK signaling

Drug-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 3THYROItissue: THYROI cancer: THYROID model num: 0THYROIDtissue: THYROID cancer: Thyroid Cancer model num: 1LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Lung Adenocarcinoma (LUAD) model num: 2BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: Colorectal Adenocarcinoma (COADREAD) model num: 1STOMACtissue: STOMAC cancer: STOMACH model num: 0STOMACHtissue: STOMACH cancer: Esophageal Adenocarcinoma (ESCA) model num: 1BONtissue: BON cancer: BONE model num: 0BONEtissue: BONE cancer: Acute Myeloid Leukemia (AML) model num: 1PANCREAtissue: PANCREA cancer: PANCREAS model num: 0PANCREAStissue: PANCREAS cancer: Pancreatic Adenocarcinoma (PAAD) model num: 1SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: Cutaneous Melanoma (SKCM) model num: 1

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
3845 KRAS 1
6597 SMARCA4 1
9757 KMT2B 1
55294 FBXW7 2
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Gene in drug-gene network: Network Plot

Models in FR-180204

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
FUS(EWSR1-FLI1) gene GDSC undefined PANCAN FR-180204 sensitivity in vitro
MUT(BRAF) gene GDSC THYROID Thyroid Cancer FR-180204 sensitivity in vitro
MUT(BRAF) gene GDSC undefined PANCAN FR-180204 sensitivity in vitro
MUT(EGFR) gene GDSC LUNG Lung Adenocarcinoma (LUAD) FR-180204 sensitivity in vitro
MUT(MLL2)&PWU(JAK-STAT)|¬DEL(3p14.2)&DEL(Xq22.3) mix GDSC undefined PANCAN FR-180204 sensitivity in vitro
MUT(CHD9)&DEL(16p13.3)|MUT(FBXW7)&MUT(SMARCA4) mix GDSC BOWEL Colorectal Adenocarcinoma (COADREAD) FR-180204 sensitivity in vitro
¬AMP(CCND1,CTTN)&(ERBB2) mix GDSC STOMACH Esophageal Adenocarcinoma (ESCA) FR-180204 sensitivity in vitro
¬MUT(FBXW7)&¬MUT(NRAS)&¬DEL(9p13.1)&¬PWU(TLR) mix GDSC BONE Acute Myeloid Leukemia (AML) FR-180204 sensitivity in vitro
MUT(EGFR) mix GDSC LUNG Lung Adenocarcinoma (LUAD) FR-180204 sensitivity in vitro
MUT(EP300)&(KRAS)|MUT(CDKN2A)&MUT(TP53) mix GDSC PANCREAS Pancreatic Adenocarcinoma (PAAD) FR-180204 sensitivity in vitro
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