iGMDRD763

Canonical SMILES: CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC

InChI: InChI=1S/C28H33N7O2/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32)

InChI Key: DUYJMQONPNNFPI-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameOsimertinib
CHEMBLCHEMBL3545063 CHEMBL3353410
Pubchem CID71496500
DRUGBANK IDDB09330
Drug StatusAlone
Drug TypeSmall Molecule


Drug Targets:

EGFR (P00533)

Drug-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Lung Cancer model num: 4LUNGtissue: LUNG cancer: Non-Small Cell Lung Cancer (NSCLC) model num: 8LUNGtissue: LUNG cancer: Lung Adenocarcinoma (LUAD) model num: 6

Drug-gene pathway enrichments

4reactome: Signaling by ERBB24reactome: Signaling by Receptor Tyrosine Kinases4reactome: SHC1 events in ERBB2 signaling4reactome: Signal Transduction3reactome: GRB2 events in ERBB2 signaling3reactome: Gene expression (Transcription)3reactome: Disease3reactome: RNA Polymerase II Transcription2kegg: Bladder cancer - Homo sapiens (human)2kegg: Prostate cancer - Homo sapiens (human)

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
2064 ERBB2 1
8731 RNMT 1
1956 EGFR 16
Showing 1 to 3 of 3 rows

Gene in drug-gene network: Network Plot

Models in Osimertinib

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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