iGMDRD762

Canonical SMILES: CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC

InChI: InChI=1S/C28H33N7O2/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24/h7-13,16-18H,1,14-15H2,2-6H3,(H,30,36)(H,29,31,32)

InChI Key: DUYJMQONPNNFPI-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameAZD-9291
CHEMBLCHEMBL3353410
Pubchem CID71496500
DRUGBANK IDDB09330
Drug StatusAlone
Drug TypeSmall Molecule


Drug Targets:

EGFR (P00533)

Drug-model tissue-cancer distribution: Bubble Plot

OTHEtissue: OTHE cancer: OTHER model num: 0OTHERtissue: OTHER cancer: Cancer of Unknown Primary (CUP) model num: 3

Drug-gene pathway enrichments

2reactome: Signal Transduction2reactome: SHC1 events in ERBB2 signaling2reactome: Signaling by ERBB22reactome: Signaling by Receptor Tyrosine Kinases2wikipathways: Ebola Virus Pathway on Host1netpath: AndrogenReceptor1reactome: Signaling by PTK61reactome: Cargo recognition for clathrin-mediated endocytosis1reactome: ERBB2 Activates PTK6 Signaling1reactome: Gastrin-CREB signalling pathway via PKC and MAPK

Drug-gene GO enrichments

5MF: protein tyrosine kinase activity4MF: epidermal growth factor-activated receptor activity3BP: positive regulation of ERK1 and ERK2 cascade3BP: epidermal growth factor receptor signaling pathway2MF: epidermal growth factor binding2BP: positive regulation of cell proliferation2CC: receptor complex2MF: transmembrane receptor protein tyrosine kinase activity2BP: positive regulation of protein kinase B signaling2BP: signal transduction

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
1956 EGFR 3
Showing 1 to 1 of 1 rows

Gene in drug-gene network: Network Plot

Models in AZD-9291

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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