iGMDRD386

Canonical SMILES: CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC(=CC=C4)C

InChI: InChI=1S/C24H21N3OS/c1-3-21-27-22(18-11-7-8-16(2)14-18)23(29-21)19-12-13-25-20(15-19)26-24(28)17-9-5-4-6-10-17/h4-15H,3H2,1-2H3,(H,25,26,28)

InChI Key: HEKAIDKUDLCBRU-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NameTAK-715
CHEMBLCHEMBL363648
Pubchem CID9952770
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

p38alphap38beta

Drug Pathways:

JNK and p38 signaling

Drug-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 2LYMPtissue: LYMP cancer: LYMPH model num: 0LYMPHtissue: LYMPH cancer: Diffuse Large B-Cell Lymphoma (DLBCL) model num: 1BONtissue: BON cancer: BONE model num: 0BONEtissue: BONE cancer: Acute Myeloid Leukemia (AML) model num: 1

Drug-gene pathway enrichments

6reactome: Signal Transduction4reactome: Signaling by Receptor Tyrosine Kinases4reactome: Signaling by ERBB24reactome: Disease3kegg: MicroRNAs in cancer - Homo sapiens (human)3kegg: Pathways in cancer - Homo sapiens (human)3kegg: Human papillomavirus infection - Homo sapiens (human)3reactome: Diseases of signal transduction3reactome: Signaling by NOTCH33reactome: Signaling by NOTCH

Drug-gene GO enrichments

7CC: plasma membrane5MF: protein tyrosine kinase activity4MF: epidermal growth factor-activated receptor activity4MF: protein binding4BP: positive regulation of ERK1 and ERK2 cascade4BP: positive regulation of cell proliferation4CC: Golgi membrane3CC: receptor complex3BP: positive regulation of transcription by RNA polymerase II3CC: membrane

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
567 B2M 1
4851 NOTCH1 1
1956 EGFR 1
4893 NRAS 1
Showing 1 to 4 of 4 rows

Gene in drug-gene network: Network Plot

Models in TAK-715

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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