iGMDRD742

Canonical SMILES: CCC(C)C1C(=O)N2CCCCC2C(=O)NC(C(=O)NC(C(=O)N1)CC3=CN(C4=CC=CC=C43)OC)CCCCCC(=O)CC

InChI: InChI=1S/C34H49N5O6/c1-5-22(3)30-34(44)38-19-13-12-18-29(38)33(43)35-26(16-9-7-8-14-24(40)6-2)31(41)36-27(32(42)37-30)20-23-21-39(45-4)28-17-11-10-15-25(23)28/h10-11,15,17,21-22,26-27,29-30H,5-9,12-14,16,18-20H2,1-4H3,(H,35,43)(H,36,41)(H,37,42)/t22-,26-,27-,29+,30?/m0/s1

InChI Key: JWOGUUIOCYMBPV-GTMVXCKXSA-N

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Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NameApicidin
CHEMBLCHEMBL430060
Pubchem CID59274500
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 1LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 2undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 8

Drug-gene pathway enrichments

2reactome: Signal Transduction2reactome: SHC1 events in ERBB2 signaling2reactome: Signaling by ERBB22reactome: Signaling by Receptor Tyrosine Kinases2wikipathways: Ebola Virus Pathway on Host1netpath: AndrogenReceptor1reactome: Signaling by PTK61reactome: Cargo recognition for clathrin-mediated endocytosis1reactome: ERBB2 Activates PTK6 Signaling1reactome: Gastrin-CREB signalling pathway via PKC and MAPK

Drug-gene GO enrichments

5MF: protein tyrosine kinase activity4MF: epidermal growth factor-activated receptor activity3BP: positive regulation of ERK1 and ERK2 cascade3BP: epidermal growth factor receptor signaling pathway2MF: epidermal growth factor binding2BP: positive regulation of cell proliferation2CC: receptor complex2MF: transmembrane receptor protein tyrosine kinase activity2BP: positive regulation of protein kinase B signaling2BP: signal transduction

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
1956 EGFR 1
Showing 1 to 1 of 1 rows

Gene in drug-gene network: Network Plot

Models in Apicidin

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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