iGMDRD735

Canonical SMILES: CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F)OC

InChI: InChI=1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,39)(H2,31,33,34,35)

InChI Key: HUFOZJXAKZVRNJ-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameCO-1686 (AVL-301)
CHEMBLCHEMBL3545308
Pubchem CID57335400
DRUGBANK IDDB11907
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Non-Small Cell Lung Cancer (NSCLC) model num: 4LUNGtissue: LUNG cancer: Lung Adenocarcinoma (LUAD) model num: 3LUNGtissue: LUNG cancer: Adenoid Cystic Carcinoma of the Lung (LUACC) model num: 1

Drug-gene pathway enrichments

4reactome: Signaling by ERBB24reactome: Signaling by Receptor Tyrosine Kinases4reactome: SHC1 events in ERBB2 signaling4reactome: Signal Transduction3reactome: GRB2 events in ERBB2 signaling3reactome: Gene expression (Transcription)3reactome: Disease3reactome: RNA Polymerase II Transcription2kegg: Bladder cancer - Homo sapiens (human)2kegg: Prostate cancer - Homo sapiens (human)

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
2064 ERBB2 1
8731 RNMT 1
1956 EGFR 6
Showing 1 to 3 of 3 rows

Gene in drug-gene network: Network Plot

Models in CO-1686 (AVL-301)

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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