iGMDRD721

Canonical SMILES: CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC4=C(C(=N3)OC5=CC=CC(=C5)NC(=O)C=C)SC=C4

InChI: InChI=1S/C26H26N6O2S/c1-3-23(33)27-19-5-4-6-21(17-19)34-25-24-22(11-16-35-24)29-26(30-25)28-18-7-9-20(10-8-18)32-14-12-31(2)13-15-32/h3-11,16-17H,1,12-15H2,2H3,(H,27,33)(H,28,29,30)

InChI Key: FDMQDKQUTRLUBU-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameHM61713
CHEMBLCHEMBL3786343
Pubchem CID54758500
DRUGBANK IDDB13164
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

EGFR (P00533)

Drug-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Non-Small Cell Lung Cancer (NSCLC) model num: 1OTHEtissue: OTHE cancer: OTHER model num: 0OTHERtissue: OTHER cancer: Cancer of Unknown Primary (CUP) model num: 1

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
1956 EGFR 2
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Gene in drug-gene network: Network Plot

Models in HM61713

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
SNV(EGFR T790M) gene NCT02322281 LUNG Non-Small Cell Lung Cancer (NSCLC) HM61713 sensitivity in vivo
SNV(EGFR C797S) gene 26749488 OTHER Cancer of Unknown Primary (CUP) HM61713 resistance in vivo
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