iGMDRD259

Canonical SMILES: C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N

InChI: InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)

InChI Key: FUZYTVDVLBBXDL-UHFFFAOYSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameEX-527
Pubchem CID5113030
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

SIRT1

Drug-model tissue-cancer distribution: Bubble Plot

OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 9LYMPtissue: LYMP cancer: LYMPH model num: 0LYMPHtissue: LYMPH cancer: Diffuse Large B-Cell Lymphoma (DLBCL) model num: 1BONtissue: BON cancer: BONE model num: 0BONEtissue: BONE cancer: Acute Myeloid Leukemia (AML) model num: 1SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: Cutaneous Melanoma (SKCM) model num: 1

Drug-gene pathway enrichments

10reactome: Signal Transduction7reactome: Signaling by Receptor Tyrosine Kinases6reactome: Hemostasis6kegg: PI3K-Akt signaling pathway - Homo sapiens (human)6wikipathways: PI3K-Akt Signaling Pathway6reactome: Immune System5kegg: Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)5kegg: MicroRNAs in cancer - Homo sapiens (human)5kegg: MAPK signaling pathway - Homo sapiens (human)5kegg: Pathways in cancer - Homo sapiens (human)

Drug-gene GO enrichments

7BP: positive regulation of transcription by RNA polymerase II7MF: protein binding7CC: cytoplasm5CC: nucleus5MF: protein tyrosine kinase activity5BP: positive regulation of gene expression5BP: positive regulation of cell proliferation5CC: membrane5CC: cytosol4BP: positive regulation of endothelial cell proliferation

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
3845 KRAS 1
55252 ASXL2 1
5159 PDGFRB 1
6850 SYK 1
Showing 1 to 4 of 8 rows

Gene in drug-gene network: Network Plot

Models in EX-527

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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