IGFBP5
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| insulin like growth factor binding protein 5 | MIM:146734 | Ensembl:ENSG00000115461 | HGNC:HGNC:5474 | PA29707 | 2q35 |
Gene Categories:
DRUGGABLE GENOMEGO terms in IGFBP5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0001968 | fibronectin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0031994 | insulin-like growth factor I binding |
| MF | IPI | GO:0031994 | insulin-like growth factor I binding |
| MF | IBA | GO:0031995 | insulin-like growth factor II binding |
| BP | IEA | GO:0001558 | regulation of cell growth |
| BP | IEA | GO:0001649 | osteoblast differentiation |
| BP | IEA | GO:0006006 | glucose metabolic process |
| BP | NAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0007565 | female pregnancy |
| BP | IEA | GO:0007568 | aging |
| BP | IEA | GO:0010906 | regulation of glucose metabolic process |
| BP | IDA | GO:0014912 | negative regulation of smooth muscle cell migration |
| BP | IDA | GO:0017148 | negative regulation of translation |
| BP | IDA | GO:0030336 | negative regulation of cell migration |
| BP | IEA | GO:0031069 | hair follicle morphogenesis |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | IEA | GO:0042593 | glucose homeostasis |
| BP | IBA | GO:0043567 | regulation of insulin-like growth factor receptor signaling pathway |
| BP | IEA | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway |
| BP | IDA | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IEA | GO:0044342 | type B pancreatic cell proliferation |
| BP | IEA | GO:0045668 | negative regulation of osteoblast differentiation |
| BP | IEA | GO:0045926 | negative regulation of growth |
| BP | IEA | GO:0048286 | lung alveolus development |
| BP | IDA | GO:0048662 | negative regulation of smooth muscle cell proliferation |
| BP | IEA | GO:0051146 | striated muscle cell differentiation |
| BP | IEA | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IEA | GO:0060056 | mammary gland involution |
| BP | ISS | GO:0060416 | response to growth hormone |
| BP | IDA | GO:0071320 | cellular response to cAMP |
| BP | IDA | GO:0071407 | cellular response to organic cyclic compound |
| BP | IEA | GO:1901862 | negative regulation of muscle tissue development |
| BP | IEA | GO:1904205 | negative regulation of skeletal muscle hypertrophy |
| BP | IGI | GO:1904707 | positive regulation of vascular smooth muscle cell proliferation |
| BP | IGI | GO:1904754 | positive regulation of vascular associated smooth muscle cell migration |
| CC | NAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | IC | GO:0016942 | insulin-like growth factor binding protein complex |
| CC | IDA | GO:0042567 | insulin-like growth factor ternary complex |
Gene expression in normal tissue: IGFBP5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IGFBP5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP3391 | Senescence-Associated Secretory Phenotype (SASP) |
| wikipathways | WP3850 | Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8957275 | Post-translational protein phosphorylation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD49 | Mitomycin | 1 |
| iGMDRD237 | ABT-751 | 4 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD177 | Teniposide | 4 |
| iGMDRD435 | BI-2536 | 1 |
| iGMDRD154 | NSC23766 | 6 |
| iGMDRD798 | Ceranib-2 | 1 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD271 | Brefeldin A | 4 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD105 | Triptolide | 5 |
| iGMDRD705 | Nakiterpiosin | 5 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD639 | YK 4-279 | 1 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD554 | CHEMBL1434137 | 2 |
| iGMDRD416 | TG100-115 | 1 |
| iGMDRD857 | BRD-K70511574 | 1 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD489 | GSK-461364 | 1 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD802 | 4-methylfasudil | 4 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD318 | PAC-1 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IGFBP5
CLASSFICATION
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