IGFBP5


Summary:

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
insulin like growth factor binding protein 5MIM:146734Ensembl:ENSG00000115461HGNC:HGNC:5474PA297072q35

Gene Categories:

DRUGGABLE GENOME

GO terms in IGFBP5


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0001968fibronectin binding
MFIPIGO:0005515protein binding
MFIBAGO:0031994insulin-like growth factor I binding
MFIPIGO:0031994insulin-like growth factor I binding
MFIBAGO:0031995insulin-like growth factor II binding
BPIEAGO:0001558regulation of cell growth
BPIEAGO:0001649osteoblast differentiation
BPIEAGO:0006006glucose metabolic process
BPNASGO:0007165signal transduction
BPIEAGO:0007565female pregnancy
BPIEAGO:0007568aging
BPIEAGO:0010906regulation of glucose metabolic process
BPIDAGO:0014912negative regulation of smooth muscle cell migration
BPIDAGO:0017148negative regulation of translation
BPIDAGO:0030336negative regulation of cell migration
BPIEAGO:0031069hair follicle morphogenesis
BPIEAGO:0035556intracellular signal transduction
BPIEAGO:0042593glucose homeostasis
BPIBAGO:0043567regulation of insulin-like growth factor receptor signaling pathway
BPIEAGO:0043568positive regulation of insulin-like growth factor receptor signaling pathway
BPIDAGO:0043569negative regulation of insulin-like growth factor receptor signaling pathway
BPTASGO:0043687post-translational protein modification
BPTASGO:0044267cellular protein metabolic process
BPIEAGO:0044342type B pancreatic cell proliferation
BPIEAGO:0045668negative regulation of osteoblast differentiation
BPIEAGO:0045926negative regulation of growth
BPIEAGO:0048286lung alveolus development
BPIDAGO:0048662negative regulation of smooth muscle cell proliferation
BPIEAGO:0051146striated muscle cell differentiation
BPIEAGO:0051897positive regulation of protein kinase B signaling
BPIEAGO:0060056mammary gland involution
BPISSGO:0060416response to growth hormone
BPIDAGO:0071320cellular response to cAMP
BPIDAGO:0071407cellular response to organic cyclic compound
BPIEAGO:1901862negative regulation of muscle tissue development
BPIEAGO:1904205negative regulation of skeletal muscle hypertrophy
BPIGIGO:1904707positive regulation of vascular smooth muscle cell proliferation
BPIGIGO:1904754positive regulation of vascular associated smooth muscle cell migration
CCNASGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCTASGO:0005788endoplasmic reticulum lumen
CCICGO:0016942insulin-like growth factor binding protein complex
CCIDAGO:0042567insulin-like growth factor ternary complex

Gene expression in normal tissue: IGFBP5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IGFBP5


DatabasePathway IDPathway Des.
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP3391Senescence-Associated Secretory Phenotype (SASP)
wikipathwaysWP3850Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling
wikipathwaysWP615Senescence and Autophagy in Cancer
reactomeR-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-8957275Post-translational protein phosphorylation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD49Mitomycin1
iGMDRD237ABT-7514
iGMDRD57Chloropentafluorobenzene2
iGMDRD314Tanespimycin3
iGMDRD123Isoevodiamine3
iGMDRD177Teniposide4
iGMDRD435BI-25361
iGMDRD154NSC237666
iGMDRD798Ceranib-21
iGMDRD512nutlin 31
iGMDRD405PIK-752
iGMDRD414MST-3122
iGMDRD871BRD63682
iGMDRD286Nsc 6328392
iGMDRD367Ro 28-16752
iGMDRD329Merck602
iGMDRD505Pevonedistat1
iGMDRD300Tozasertib2
iGMDRD271Brefeldin A4
iGMDRD158NSC1415402
iGMDRD105Triptolide5
iGMDRD705Nakiterpiosin5
iGMDRD446LY 21832402
iGMDRD639YK 4-2791
iGMDRD375GW-4058332
iGMDRD554CHEMBL14341372
iGMDRD416TG100-1151
iGMDRD857BRD-K705115741
iGMDRD781Sirolimus3
iGMDRD489GSK-4613641
iGMDRD494Neopeltolide2
iGMDRD74Idarubicin3
iGMDRD188Piperlongumine5
iGMDRD506Fedratinib1
iGMDRD60Quinoclamine2
iGMDRD451Serdemetan2
iGMDRD23Gossypol1
iGMDRD8024-methylfasudil4
iGMDRD255SB2250022
iGMDRD187BRD98761
iGMDRD294Batimastat2
iGMDRD318PAC-11

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IGFBP5

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