iGMDRD477

Canonical SMILES: CC(C)C1=C(C=C(C(=C1)C(=O)N2CC3=C(C2)C=C(C=C3)CN4CCN(CC4)C)O)O

InChI: InChI=1S/C24H31N3O3/c1-16(2)20-11-21(23(29)12-22(20)28)24(30)27-14-18-5-4-17(10-19(18)15-27)13-26-8-6-25(3)7-9-26/h4-5,10-12,16,28-29H,6-9,13-15H2,1-3H3

InChI Key: IFRGXKKQHBVPCQ-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NameAT13387
CHEMBLCHEMBL1214827 CHEMBL3301599
Pubchem CID11955700
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

HSP90AA1

Drug-model tissue-cancer distribution: Bubble Plot

PANCREAtissue: PANCREA cancer: PANCREAS model num: 0PANCREAStissue: PANCREAS cancer: undefined model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 6undefinedtissue: undefined cancer: Lymphoma model num: 1

Drug-gene pathway enrichments

2kegg: Transcriptional misregulation in cancer - Homo sapiens (human)2reactome: RNA Polymerase II Transcription2reactome: Generic Transcription Pathway2reactome: Gene expression (Transcription)2wikipathways: miR-targeted genes in lymphocytes - TarBase2reactome: Signaling by TGF-beta family members2wikipathways: Ebola Virus Pathway on Host2pid: ALK1 signaling events2reactome: Signal Transduction2reactome: Signaling by BMP

Drug-gene GO enrichments

7CC: nucleus6MF: protein binding6BP: BMP signaling pathway5MF: RNA polymerase II transcription factor activity, sequence-specific DNA binding5BP: mismatch repair5CC: nucleoplasm4BP: positive regulation of transcription by RNA polymerase II4CC: integral component of plasma membrane4MF: ATP binding3CC: cytoplasm

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
2956 MSH6 1
604 BCL6 1
4086 SMAD1 1
7301 TYRO3 1
Showing 1 to 4 of 5 rows

Gene in drug-gene network: Network Plot

Models in AT13387

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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