BCL6
Summary: The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| B cell CLL/lymphoma 6 | MIM:109565 | Ensembl:ENSG00000113916 | HGNC:HGNC:1001 | PA25312 | 3q27.3 |
GO terms in BCL6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IGI | GO:0000060 | protein import into nucleus, translocation |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0000902 | cell morphogenesis |
| BP | IEA | GO:0001953 | negative regulation of cell-matrix adhesion |
| BP | IEA | GO:0002467 | germinal center formation |
| BP | NAS | GO:0002634 | regulation of germinal center formation |
| BP | NAS | GO:0002903 | negative regulation of B cell apoptotic process |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IEA | GO:0007266 | Rho protein signal transduction |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0030036 | actin cytoskeleton organization |
| BP | IEA | GO:0030183 | B cell differentiation |
| BP | IDA | GO:0030308 | negative regulation of cell growth |
| BP | IEA | GO:0030890 | positive regulation of B cell proliferation |
| BP | IEA | GO:0031065 | positive regulation of histone deacetylation |
| BP | IEA | GO:0032764 | negative regulation of mast cell cytokine production |
| BP | IEA | GO:0035024 | negative regulation of Rho protein signal transduction |
| BP | IBA | GO:0042092 | type 2 immune response |
| BP | IBA | GO:0042127 | regulation of cell proliferation |
| BP | TAS | GO:0042981 | regulation of apoptotic process |
| BP | IDA | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:0043087 | regulation of GTPase activity |
| BP | IEA | GO:0043380 | regulation of memory T cell differentiation |
| BP | IMP | GO:0045591 | positive regulation of regulatory T cell differentiation |
| BP | IBA | GO:0045595 | regulation of cell differentiation |
| BP | IEA | GO:0045629 | negative regulation of T-helper 2 cell differentiation |
| BP | IEA | GO:0045666 | positive regulation of neuron differentiation |
| BP | IEA | GO:0045746 | negative regulation of Notch signaling pathway |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | NAS | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IEA | GO:0048294 | negative regulation of isotype switching to IgE isotypes |
| BP | IEA | GO:0048821 | erythrocyte development |
| BP | IBA | GO:0050727 | regulation of inflammatory response |
| BP | NAS | GO:0050776 | regulation of immune response |
| BP | IEA | GO:0051272 | positive regulation of cellular component movement |
| BP | NAS | GO:1903464 | negative regulation of mitotic cell cycle DNA replication |
| BP | IEA | GO:2000773 | negative regulation of cellular senescence |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005657 | replication fork |
| CC | IDA | GO:0005794 | Golgi apparatus |
| MF | IBA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | IEA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0001161 | intronic transcription regulatory region sequence-specific DNA binding |
| MF | IBA | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IEA | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IBA | GO:0003677 | DNA binding |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | IMP | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0031490 | chromatin DNA binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0043565 | sequence-specific DNA binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: BCL6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BCL6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| wikipathways | WP2002 | miR-targeted genes in epithelium - TarBase |
| wikipathways | WP2003 | miR-targeted genes in leukocytes - TarBase |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP3584 | MECP2 and Associated Rett Syndrome |
| wikipathways | WP3802 | TP53 Regulates Transcription of Cell Death Genes |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| netpath | Pathway_BCR | BCR |
| pid | foxopathway | FoxO family signaling |
| pid | hdac_classii_pathway | Signaling events mediated by HDAC Class II |
| pid | il4_2pathway | IL4-mediated signaling events |
| pid | p53downstreampathway | Direct p53 effectors |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD477 | AT13387 | 1 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD148 | Pifithrin-mu | 2 |
| iGMDRD584 | VER 155008 | 1 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD427 | ABT737 | 5 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD318 | PAC-1 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BCL6
CLASSFICATION
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