CPAMD8


Summary: This gene encodes a member of the protease inhibitor I39 (alpha-2-macroglobulin) family of proteins. These proteins are important in innate and acquired immunity. The encoded protein is membrane-associated and proteolytically processed to generate two chains. Mutations in this gene cause a form of anterior segment dysgenesis, a developmental disorder of the eye. [provided by RefSeq, May 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
C3 and PZP like, alpha-2-macroglobulin domain containing 8MIM:608841Ensembl:ENSG00000160111HGNC:HGNC:23228PA13491505719p13.11

GO terms in CPAMD8


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0005615extracellular space
CCIEAGO:0005886plasma membrane
BPIMPGO:0001654eye development
BPIEAGO:0010951negative regulation of endopeptidase activity
MFIEAGO:0004867serine-type endopeptidase inhibitor activity

Gene expression in normal tissue: CPAMD8

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CPAMD8


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD780PP-302
iGMDRD398Sepantronium2
iGMDRD562Navitoclax6
iGMDRD577BIX012942
iGMDRD871BRD63682
iGMDRD188Piperlongumine2
iGMDRD552AZD-17752
iGMDRD886Compound 1541A2
iGMDRD255SB2250022
iGMDRD138PX 122
iGMDRD474Avrainvillamide2
iGMDRD137Indisulam3
iGMDRD77Itraconazole2
iGMDRD318PAC-12
iGMDRD434BMS-5369242
iGMDRD152179324-69-74
iGMDRD314Tanespimycin3
iGMDRD57Chloropentafluorobenzene2
iGMDRD639YK 4-2793
iGMDRD446LY 21832403
iGMDRD511CHEMBL3993793
iGMDRD280CYTOCHALASIN B2
iGMDRD211(1S,3R)-RSL32
iGMDRD84Lovastatin acid2
iGMDRD781Sirolimus4
iGMDRD427ABT7373
iGMDRD560MK-22062

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CPAMD8

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