LAMP1
Summary: The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| lysosomal associated membrane protein 1 | MIM:153330 | Ensembl:ENSG00000185896 | HGNC:HGNC:6499 | PA30283 | 13q34 |
GO terms in LAMP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0008626 | granzyme-mediated apoptotic signaling pathway |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IMP | GO:0043323 | positive regulation of natural killer cell degranulation |
| BP | IMP | GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity |
| BP | IEA | GO:0046718 | viral entry into host cell |
| BP | IEA | GO:0048102 | autophagic cell death |
| BP | ISS | GO:0050821 | protein stabilization |
| BP | IMP | GO:0072594 | establishment of protein localization to organelle |
| BP | IMP | GO:0090160 | Golgi to lysosome transport |
| BP | IMP | GO:1902513 | regulation of organelle transport along microtubule |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005764 | lysosome |
| CC | IDA | GO:0005764 | lysosome |
| CC | ISS | GO:0005765 | lysosomal membrane |
| CC | IDA | GO:0005770 | late endosome |
| CC | IEA | GO:0005771 | multivesicular body |
| CC | IEA | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0008021 | synaptic vesicle |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | ISS | GO:0010008 | endosome membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0030425 | dendrite |
| CC | TAS | GO:0035577 | azurophil granule membrane |
| CC | IEA | GO:0042383 | sarcolemma |
| CC | IEA | GO:0042470 | melanosome |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IEA | GO:0044194 | cytolytic granule |
| CC | IEA | GO:0044754 | autolysosome |
| CC | IMP | GO:0048471 | perinuclear region of cytoplasm |
| CC | IEA | GO:0061474 | phagolysosome membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IEA | GO:0097208 | alveolar lamellar body |
| CC | TAS | GO:0101003 | ficolin-1-rich granule membrane |
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IEA | GO:0019904 | protein domain specific binding |
Gene expression in normal tissue: LAMP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LAMP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04142 | Lysosome - Homo sapiens (human) |
| kegg | hsa04145 | Phagosome - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD554 | CHEMBL1434137 | 1 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD103 | SN-38 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LAMP1
CLASSFICATION
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