PRAME
Summary: This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:606021 Ensembl IDEnsembl:ENSG00000185686 HGNC IDHGNC:HGNC:9336 PHARMGKB IDPA33698 Map Location22q11.22 | |||||
GO terms in PRAME
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0042974 | retinoic acid receptor binding |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0030154 | cell differentiation |
Gene expression in normal tissue: PRAME
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRAME
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRAME
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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