CRKL
Summary: This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602007 Ensembl IDEnsembl:ENSG00000099942 HGNC IDHGNC:HGNC:2363 PHARMGKB IDPA26881 Map Location22q11.21 | |||||
GO terms in CRKL
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000186 | activation of MAPKK activity |
| BP | IEA | GO:0001568 | blood vessel development |
| BP | IMP | GO:0001933 | negative regulation of protein phosphorylation |
| BP | IMP | GO:0001934 | positive regulation of protein phosphorylation |
| BP | TAS | GO:0007254 | JNK cascade |
| BP | TAS | GO:0007265 | Ras protein signal transduction |
Gene expression in normal tissue: CRKL
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CRKL
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | at1rpathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling |
| biocarta | gleevecpathway | inhibition of cellular proliferation by gleevec |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| biocarta | integrinpathway | integrin signaling pathway |
| biocarta | pyk2pathway | links between pyk2 and map kinases |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CRKL
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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