CRKL
Summary: This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CRK like proto-oncogene, adaptor protein | MIM:602007 | Ensembl:ENSG00000099942 | HGNC:HGNC:2363 | PA26881 | 22q11.21 |
GO terms in CRKL
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000186 | activation of MAPKK activity |
| BP | IEA | GO:0001568 | blood vessel development |
| BP | IMP | GO:0001933 | negative regulation of protein phosphorylation |
| BP | IMP | GO:0001934 | positive regulation of protein phosphorylation |
| BP | TAS | GO:0007254 | JNK cascade |
| BP | TAS | GO:0007265 | Ras protein signal transduction |
| BP | IEA | GO:0007507 | heart development |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0009887 | animal organ morphogenesis |
| BP | IEA | GO:0009952 | anterior/posterior pattern specification |
| BP | IMP | GO:0010629 | negative regulation of gene expression |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0035556 | intracellular signal transduction |
| BP | IEA | GO:0048538 | thymus development |
| BP | IEA | GO:0060017 | parathyroid gland development |
| BP | IMP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| BP | IMP | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading |
| BP | IMP | GO:1903977 | positive regulation of glial cell migration |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005768 | endosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| MF | IPI | GO:0001784 | phosphotyrosine residue binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | TAS | GO:0005070 | SH3/SH2 adaptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | HDA | GO:0045296 | cadherin binding |
Gene expression in normal tissue: CRKL
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CRKL
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | at1rpathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling |
| biocarta | gleevecpathway | inhibition of cellular proliferation by gleevec |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| biocarta | integrinpathway | integrin signaling pathway |
| biocarta | pyk2pathway | links between pyk2 and map kinases |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-169893 | Prolonged ERK activation events |
| reactome | R-HSA-169893 | Prolonged ERK activation events |
| reactome | R-HSA-170968 | Frs2-mediated activation |
| reactome | R-HSA-170968 | Frs2-mediated activation |
| reactome | R-HSA-186763 | Downstream signal transduction |
| reactome | R-HSA-186797 | Signaling by PDGF |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187687 | Signalling to ERKs |
| reactome | R-HSA-187687 | Signalling to ERKs |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-6806834 | Signaling by MET |
| reactome | R-HSA-8875555 | MET activates RAP1 and RAC1 |
| reactome | R-HSA-8875656 | MET receptor recycling |
| reactome | R-HSA-8875878 | MET promotes cell motility |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-912631 | Regulation of signaling by CBL |
| wikipathways | WP2263 | Androgen Receptor Network in Prostate Cancer |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP286 | IL-3 Signaling Pathway |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP313 | Signaling of Hepatocyte Growth Factor Receptor |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP4205 | MET in type 1 papillary renal cell carcinoma |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP49 | IL-2 Signaling Pathway |
| wikipathways | WP585 | Interferon type I signaling pathways |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| pid | epha_fwdpathway | EPHA forward signaling |
| pid | epopathway | EPO signaling pathway |
| pid | ifngpathway | IFN-gamma pathway |
| pid | igf1_pathway | IGF1 pathway |
| pid | kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | pdgfrapathway | PDGFR-alpha signaling pathway |
| pid | reelinpathway | Reelin signaling pathway |
| pid | tcrjnkpathway | JNK signaling in the CD4+ TCR pathway |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
| kegg | hsa05131 | Shigellosis - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL3 | IL3 |
| netpath | Pathway_IL5 | IL5 |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_TCR | TCR |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD61 | Kinetin riboside | 5 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD577 | BIX01294 | 1 |
| iGMDRD662 | JQ-1 | 1 |
| iGMDRD888 | Compound 44 | 4 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD268 | Cerulenin | 1 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD289 | Parthenolide | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CRKL
CLASSFICATION
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