VRK2
Summary: This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. The encoded protein acts as an effector of signaling pathways that regulate apoptosis and tumor cell growth. Variants in this gene have been associated with schizophrenia. Alternative splicing results in multiple transcript variants that differ in their subcellular localization and biological activity. [provided by RefSeq, Jan 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| vaccinia related kinase 2 | MIM:602169 | Ensembl:ENSG00000028116 | HGNC:HGNC:12719 | PA37331 | 2p16.1 |
GO terms in VRK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0031966 | mitochondrial membrane |
| CC | IDA | GO:0032991 | protein-containing complex |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0016032 | viral process |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IMP | GO:0034599 | cellular response to oxidative stress |
| BP | IMP | GO:0043408 | regulation of MAPK cascade |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IMP | GO:2000659 | regulation of interleukin-1-mediated signaling pathway |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0019901 | protein kinase binding |
| MF | IDA | GO:0019904 | protein domain specific binding |
Gene expression in normal tissue: VRK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in VRK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-2980766 | Nuclear Envelope Breakdown |
| reactome | R-HSA-2993913 | Clearance of Nuclear Envelope Membranes from Chromatin |
| reactome | R-HSA-2995383 | Initiation of Nuclear Envelope Reformation |
| reactome | R-HSA-2995410 | Nuclear Envelope Reassembly |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD187 | BRD9876 | 4 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD64 | Parbendazole | 5 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD562 | Navitoclax | 8 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD229 | B02 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD231 | Importazole | 3 |
| iGMDRD121 | GMX1778 | 5 |
| iGMDRD246 | NPC26 | 1 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD322 | FK 866 | 5 |
| iGMDRD269 | Purmorphamine | 2 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD123 | Isoevodiamine | 5 |
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in VRK2
CLASSFICATION
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