CNBP
Summary: This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion from <30 repeats to 75-11000 repeats in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CCHC-type zinc finger nucleic acid binding protein | MIM:116955 | Ensembl:ENSG00000169714 | HGNC:HGNC:13164 | PA37737 | 3q21.3 |
GO terms in CNBP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | IDA | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IEA | GO:0003697 | single-stranded DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IEA | GO:0003727 | single-stranded RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| CC | ISS | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | ISS | GO:0005783 | endoplasmic reticulum |
| CC | ISS | GO:0005829 | cytosol |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0006695 | cholesterol biosynthetic process |
| BP | ISS | GO:0008284 | positive regulation of cell proliferation |
| BP | ISS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
Gene expression in normal tissue: CNBP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CNBP
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD100 | Zebularine | 2 |
| iGMDRD61 | Kinetin riboside | 6 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD210 | AC55649 | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD782 | DC-45-A2 | 1 |
| iGMDRD231 | Importazole | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CNBP
CLASSFICATION
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