STK4
Summary: The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| serine/threonine kinase 4 | MIM:604965 | Ensembl:ENSG00000101109 | HGNC:HGNC:11408 | PA36215 | 20q13.12 |
GO terms in STK4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016604 | nuclear body |
| CC | IDA | GO:0032991 | protein-containing complex |
| BP | IDA | GO:0000902 | cell morphogenesis |
| BP | IEA | GO:0001569 | branching involved in blood vessel morphogenesis |
| BP | IEA | GO:0001841 | neural tube formation |
| BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IEA | GO:0003157 | endocardium development |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006915 | apoptotic process |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IEA | GO:0007417 | central nervous system development |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IEA | GO:0030216 | keratinocyte differentiation |
| BP | IDA | GO:0032092 | positive regulation of protein binding |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IDA | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IBA | GO:0035329 | hippo signaling |
| BP | IDA | GO:0035329 | hippo signaling |
| BP | TAS | GO:0035329 | hippo signaling |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:0045600 | positive regulation of fat cell differentiation |
| BP | IEA | GO:0046621 | negative regulation of organ growth |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IDA | GO:0050821 | protein stabilization |
| BP | IEA | GO:0060215 | primitive hemopoiesis |
| BP | IEA | GO:0060706 | cell differentiation involved in embryonic placenta development |
| BP | IEA | GO:0060800 | regulation of cell differentiation involved in embryonic placenta development |
| BP | IEA | GO:0071902 | positive regulation of protein serine/threonine kinase activity |
| BP | IMP | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IEA | GO:0097284 | hepatocyte apoptotic process |
| BP | IEA | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IEA | GO:1905461 | positive regulation of vascular associated smooth muscle cell apoptotic process |
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | IGI | GO:0004672 | protein kinase activity |
| MF | EXP | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | TAS | GO:0043539 | protein serine/threonine kinase activator activity |
| MF | IDA | GO:0046983 | protein dimerization activity |
Gene expression in normal tissue: STK4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STK4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| netpath | Pathway_TCR | TCR |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-2028269 | Signaling by Hippo |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD61 | Kinetin riboside | 5 |
| iGMDRD152 | 179324-69-7 | 7 |
| iGMDRD639 | YK 4-279 | 1 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD371 | THR1 Inhibitor | 1 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD319 | SB-715992 | 1 |
| iGMDRD512 | nutlin 3 | 5 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD886 | Compound 1541A | 5 |
| iGMDRD505 | Pevonedistat | 4 |
| iGMDRD655 | SCHEMBL618594 | 1 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD293 | Bleomycin | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STK4
CLASSFICATION
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