iGMDRD319

Canonical SMILES: CC1=CC=C(C=C1)C(=O)N(CCCN)C(C2=NC3=C(C=CC(=C3)Cl)C(=O)N2CC4=CC=CC=C4)C(C)C

InChI: InChI=1S/C30H33ClN4O2/c1-20(2)27(34(17-7-16-32)29(36)23-12-10-21(3)11-13-23)28-33-26-18-24(31)14-15-25(26)30(37)35(28)19-22-8-5-4-6-9-22/h4-6,8-15,18,20,27H,7,16-17,19,32H2,1-3H3/t27-/m1/s1

InChI Key: QJZRFPJCWMNVAV-HHHXNRCGSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameSB-715992
Pubchem CID6851740
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

KIF11KSP

Drug Pathways:

Mitosis

Drug-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 5LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Lung Squamous Cell Carcinoma (LUSC) model num: 1

Drug-gene pathway enrichments

2reactome: Deubiquitination2reactome: Post-translational protein modification2reactome: Signal Transduction2reactome: Metabolism of proteins2kegg: Pathways in cancer - Homo sapiens (human)2kegg: FoxO signaling pathway - Homo sapiens (human)1reactome: Disease1reactome: PTEN Regulation1reactome: Ovarian tumor domain proteases1reactome: Ub-specific processing proteases

Drug-gene GO enrichments

4CC: cytosol4CC: cytoplasm4CC: nucleoplasm3MF: protein binding3MF: protein serine/threonine kinase activity3BP: negative regulation of cell proliferation3BP: hippo signaling3CC: nucleus2MF: inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity2MF: phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
5728 PTEN 1
171023 ASXL1 1
6789 STK4 1
Showing 1 to 3 of 3 rows

Gene in drug-gene network: Network Plot

Models in SB-715992

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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