NSD3

Summary: This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namenuclear receptor binding SET domain protein 3
OMIM IDMIM:607083
Ensembl IDEnsembl:ENSG00000147548
HGNC IDHGNC:HGNC:12767
PHARMGKB IDPA37370
Map Location8p11.23

GO terms in NSD3


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IC GO:0005634 nucleus
CC TAS GO:0005654 nucleoplasm
CC IEA GO:0005694 chromosome
BP IEA GO:0006351 transcription, DNA-templated
BP IEA GO:0006355 regulation of transcription, DNA-templated
BP IDA GO:0016571 histone methylation
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Gene expression in normal tissue: NSD3

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 19LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 23undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 60undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 21undefinedtissue: undefined cancer: NON_SMALL_CELL_CARCINOMA model num: 2UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 2

Gene-drug pathway distribution

Pathways in NSD3


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Database
Pathway ID
Pathway Des.
kegg hsa00310 Lysine degradation - Homo sapiens (human)
reactome R-HSA-3214841 PKMTs methylate histone lysines
reactome R-HSA-3247509 Chromatin modifying enzymes
reactome R-HSA-4839726 Chromatin organization
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD356 PNU-74654 3
iGMDRD23 Gossypol 2
iGMDRD188 Piperlongumine 2
iGMDRD100 Zebularine 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NSD3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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