NSD3
Summary: This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nuclear receptor binding SET domain protein 3 | MIM:607083 | Ensembl:ENSG00000147548 | HGNC:HGNC:12767 | PA37370 | 8p11.23 |
GO terms in NSD3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IC | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005694 | chromosome |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IDA | GO:0016571 | histone methylation |
| BP | IEA | GO:0034968 | histone lysine methylation |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0018024 | histone-lysine N-methyltransferase activity |
| MF | TAS | GO:0018024 | histone-lysine N-methyltransferase activity |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: NSD3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NSD3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00310 | Lysine degradation - Homo sapiens (human) |
| reactome | R-HSA-3214841 | PKMTs methylate histone lysines |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-4839726 | Chromatin organization |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD318 | PAC-1 | 4 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD802 | 4-methylfasudil | 6 |
| iGMDRD255 | SB225002 | 4 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD61 | Kinetin riboside | 7 |
| iGMDRD193 | Fqi1 | 4 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD144 | NSC95397 | 4 |
| iGMDRD779 | PRL-3 Inhibitor I | 1 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD300 | Tozasertib | 7 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD267 | Oligomycin A | 4 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD202 | Curcumin | 1 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD341 | Triacsin c | 7 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD150 | RITA | 8 |
| iGMDRD405 | PIK-75 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NSD3
CLASSFICATION
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