Summary: This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].

endothelin 1MIM:131240Ensembl:ENSG00000078401HGNC:HGNC:3176PA276146p24.1

GO terms in EDN1

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
CCIDAGO:0005615extracellular space
CCTASGO:0030133transport vesicle
CCIEAGO:0033093Weibel-Palade body
CCIEAGO:0045178basal part of cell
CCIEAGO:0048237rough endoplasmic reticulum lumen
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIDAGO:0001516prostaglandin biosynthetic process
BPIEAGO:0001569branching involved in blood vessel morphogenesis
BPIEAGO:0001701in utero embryonic development
BPIEAGO:0001821histamine secretion
BPIDAGO:0003100regulation of systemic arterial blood pressure by endothelin
BPIEAGO:0006885regulation of pH
BPIDAGO:0007166cell surface receptor signaling pathway
BPIDAGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIEAGO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
BPIDAGO:0007204positive regulation of cytosolic calcium ion concentration
BPIEAGO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway
BPIDAGO:0007267cell-cell signaling
BPIEAGO:0007507heart development
BPIEAGO:0007585respiratory gaseous exchange
BPIEAGO:0007589body fluid secretion
BPIDAGO:0008284positive regulation of cell proliferation
BPIEAGO:0009953dorsal/ventral pattern formation
BPIEAGO:0010193response to ozone
BPIEAGO:0010259multicellular organism aging
BPIDAGO:0010460positive regulation of heart rate
BPIEAGO:0010469regulation of signaling receptor activity
BPTASGO:0010595positive regulation of endothelial cell migration
BPIDAGO:0010613positive regulation of cardiac muscle hypertrophy
BPIEAGO:0010827regulation of glucose transmembrane transport
BPIDAGO:0010870positive regulation of receptor biosynthetic process
BPIEAGO:0014032neural crest cell development
BPIDAGO:0014065phosphatidylinositol 3-kinase signaling
BPIEAGO:0014823response to activity
BPIDAGO:0014824artery smooth muscle contraction
BPTASGO:0014824artery smooth muscle contraction
BPIDAGO:0014826vein smooth muscle contraction
BPIEAGO:0019229regulation of vasoconstriction
BPIEAGO:0019233sensory perception of pain
BPIDAGO:0019722calcium-mediated signaling
BPIDAGO:0030072peptide hormone secretion
BPIDAGO:0030185nitric oxide transport
BPTASGO:0030195negative regulation of blood coagulation
BPIDAGO:0030335positive regulation of cell migration
BPIDAGO:0030593neutrophil chemotaxis
BPIEAGO:0031583phospholipase D-activating G-protein coupled receptor signaling pathway
BPIDAGO:0032269negative regulation of cellular protein metabolic process
BPIEAGO:0032308positive regulation of prostaglandin secretion
BPIEAGO:0032496response to lipopolysaccharide
BPIEAGO:0033574response to testosterone
BPIEAGO:0034392negative regulation of smooth muscle cell apoptotic process
BPIEAGO:0034696response to prostaglandin F
BPIEAGO:0035094response to nicotine
BPIEAGO:0035690cellular response to drug
BPIEAGO:0035810positive regulation of urine volume
BPIEAGO:0035815positive regulation of renal sodium excretion
BPIEAGO:0035994response to muscle stretch
BPIEAGO:0042045epithelial fluid transport
BPIDAGO:0042313protein kinase C deactivation
BPIEAGO:0042474middle ear morphogenesis
BPIEAGO:0042482positive regulation of odontogenesis
BPIEAGO:0042554superoxide anion generation
BPIEAGO:0043179rhythmic excitation
BPIEAGO:0043200response to amino acid
BPIDAGO:0043406positive regulation of MAP kinase activity
BPIDAGO:0043507positive regulation of JUN kinase activity
BPIEAGO:0044321response to leptin
BPTASGO:0045321leukocyte activation
BPTASGO:0045429positive regulation of nitric oxide biosynthetic process
BPIDAGO:0045793positive regulation of cell size
BPIDAGO:0045840positive regulation of mitotic nuclear division
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0045987positive regulation of smooth muscle contraction
BPIDAGO:0046887positive regulation of hormone secretion
BPIEAGO:0046888negative regulation of hormone secretion
BPIDAGO:0048016inositol phosphate-mediated signaling
BPIDAGO:0048661positive regulation of smooth muscle cell proliferation
BPIDAGO:0051091positive regulation of DNA-binding transcription factor activity
BPIEAGO:0051216cartilage development
BPIEAGO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
BPIDAGO:0051771negative regulation of nitric-oxide synthase biosynthetic process
BPIEAGO:0051899membrane depolarization
BPIEAGO:0051930regulation of sensory perception of pain
BPIEAGO:0060137maternal process involved in parturition
BPIMPGO:0060298positive regulation of sarcomere organization
BPIMPGO:0060585positive regulation of prostaglandin-endoperoxide synthase activity
BPIDAGO:0061051positive regulation of cell growth involved in cardiac muscle cell development
BPIGIGO:0061051positive regulation of cell growth involved in cardiac muscle cell development
BPICGO:0070101positive regulation of chemokine-mediated signaling pathway
BPIEAGO:0071277cellular response to calcium ion
BPIEAGO:0071346cellular response to interferon-gamma
BPIEAGO:0071347cellular response to interleukin-1
BPIEAGO:0071356cellular response to tumor necrosis factor
BPIEAGO:0071375cellular response to peptide hormone stimulus
BPIEAGO:0071385cellular response to glucocorticoid stimulus
BPIEAGO:0071389cellular response to mineralocorticoid stimulus
BPIEAGO:0071398cellular response to fatty acid
BPIEAGO:0071456cellular response to hypoxia
BPIEAGO:0071548response to dexamethasone
BPIEAGO:0071560cellular response to transforming growth factor beta stimulus
BPIEAGO:0090023positive regulation of neutrophil chemotaxis
BPIEAGO:1901224positive regulation of NIK/NF-kappaB signaling
BPIEAGO:1902074response to salt
BPIEAGO:1904707positive regulation of vascular smooth muscle cell proliferation
MFIDAGO:0005125cytokine activity
MFIDAGO:0005179hormone activity
MFIPIGO:0005515protein binding
MFIDAGO:0031707endothelin A receptor binding
MFIDAGO:0031708endothelin B receptor binding
MFIPIGO:0031708endothelin B receptor binding

Gene expression in normal tissue: EDN1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EDN1

DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373076Class A/1 (Rhodopsin-like receptors)
reactomeR-HSA-375276Peptide ligand-binding receptors
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-500792GPCR ligand binding
biocartabarrestinpathway-arrestins in gpcr desensitization
biocartabarrestinsrcpathwayroles of arrestin dependent recruitment of src kinases in gpcr signaling
biocartabarrmapkpathwayrole of -arrestins in the activation and targeting of map kinases
biocartacardiacegfpathwayrole of egf receptor transactivation by gpcrs in cardiac hypertrophy
biocartacftrpathwaycystic fibrosis transmembrane conductance regulator (cftr) and beta 2 adrenergic receptor (b2ar) pathway
biocartachrebppathwaychrebp regulation by carbohydrates and camp
biocartacskpathwayactivation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor
biocartagcrpathwaycorticosteroids and cardioprotection
biocartagspathwayactivation of camp-dependent protein kinase pka
biocartahifpathwayhypoxia-inducible factor in the cardivascular system
biocartanfatpathwaynfat and hypertrophy of the heart
biocartapkcpathwayactivation of pkc through g-protein coupled receptors
biocartaraccpathwayion channels and their functional role in vascular endothelium
biocartatubbypathwayg-protein signaling through tubby proteins
pidap1_pathwayAP-1 transcription factor network
pidet_egfrpathwayEGFR-dependent Endothelin signaling events
pidhif1_tfpathwayHIF-1-alpha transcription factor network
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04916Melanogenesis - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
wikipathwaysWP1528Physiological and Pathological Hypertrophy of the Heart
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP2197Endothelin Pathways
wikipathwaysWP3298Melatonin metabolism and effects
wikipathwaysWP3614Photodynamic therapy-induced HIF-1 survival signaling
wikipathwaysWP3624Lung fibrosis
wikipathwaysWP98Prostaglandin Synthesis and Regulation

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD886Compound 1541A3
iGMDRD341Triacsin c4
iGMDRD61Kinetin riboside1
iGMDRD889Compound 7d-cis3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EDN1