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EDN1

Summary: This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameendothelin 1 OMIM IDMIM:131240 Ensembl IDEnsembl:ENSG00000078401 HGNC IDHGNC:HGNC:3176 PHARMGKB IDPA27614 Map Location6p24.1

Gene Categories:

HORMONE ACTIVITY DRUG RESISTANCE DRUGGABLE GENOME KINASE SERINE THREONINE KINASE TUMOR SUPPRESSOR

GO terms in EDN1

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	TAS	GO:0005576	extracellular region
CC	IDA	GO:0005615	extracellular space
CC	IDA	GO:0005737	cytoplasm
CC	TAS	GO:0030133	transport vesicle
CC	IEA	GO:0033093	Weibel-Palade body
CC	IEA	GO:0045178	basal part of cell

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Gene expression in normal tissue: EDN1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EDN1

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-372790	Signaling by GPCR
reactome	R-HSA-373076	Class A/1 (Rhodopsin-like receptors)
reactome	R-HSA-375276	Peptide ligand-binding receptors
reactome	R-HSA-388396	GPCR downstream signalling
reactome	R-HSA-416476	G alpha (q) signalling events

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD886	Compound 1541A	3
iGMDRD341	Triacsin c	4
iGMDRD577	BIX01294	3
iGMDRD61	Kinetin riboside	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EDN1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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