DGKB
Summary: Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:604070 Ensembl IDEnsembl:ENSG00000136267 HGNC IDHGNC:HGNC:2850 PHARMGKB IDPA27311 Map Location7p21.2 |
Gene Categories:
KINASEGO terms in DGKB
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IEA | GO:0003951 | NAD+ kinase activity |
MF | IDA | GO:0004143 | diacylglycerol kinase activity |
MF | TAS | GO:0004143 | diacylglycerol kinase activity |
MF | IEA | GO:0005509 | calcium ion binding |
MF | IEA | GO:0005524 | ATP binding |
CC | IEA | GO:0005737 | cytoplasm |
Gene expression in normal tissue: DGKB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DGKB
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Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-109582 | Hemostasis |
reactome | R-HSA-114508 | Effects of PIP2 hydrolysis |
reactome | R-HSA-162582 | Signal Transduction |
reactome | R-HSA-372790 | Signaling by GPCR |
reactome | R-HSA-388396 | GPCR downstream signalling |
reactome | R-HSA-416476 | G alpha (q) signalling events |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in DGKB
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |