DGKB


Summary: Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:604070
PHARMGKB IDPA27311
Map Location7p21.2

Gene Categories:

KINASE

GO terms in DGKB


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0003951 NAD+ kinase activity
MF IDA GO:0004143 diacylglycerol kinase activity
MF TAS GO:0004143 diacylglycerol kinase activity
MF IEA GO:0005509 calcium ion binding
MF IEA GO:0005524 ATP binding
CC IEA GO:0005737 cytoplasm
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Gene expression in normal tissue: DGKB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DGKB


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109582 Hemostasis
reactome R-HSA-114508 Effects of PIP2 hydrolysis
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-372790 Signaling by GPCR
reactome R-HSA-388396 GPCR downstream signalling
reactome R-HSA-416476 G alpha (q) signalling events
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD474 Avrainvillamide 1
iGMDRD513 BML-259 2
iGMDRD255 SB225002 5
iGMDRD187 BRD9876 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DGKB

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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