DGKB


Summary: Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
diacylglycerol kinase betaMIM:604070Ensembl:ENSG00000136267HGNC:HGNC:2850PA273117p21.2

Gene Categories:

KINASE

GO terms in DGKB


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003951NAD+ kinase activity
MFIDAGO:0004143diacylglycerol kinase activity
MFTASGO:0004143diacylglycerol kinase activity
MFIEAGO:0005509calcium ion binding
MFIEAGO:0005524ATP binding
CCIEAGO:0005737cytoplasm
CCTASGO:0005886plasma membrane
BPIEAGO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway
BPTASGO:0030168platelet activation
BPIEAGO:0035556intracellular signal transduction
BPIDAGO:0046486glycerolipid metabolic process
BPIDAGO:0046834lipid phosphorylation

Gene expression in normal tissue: DGKB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DGKB


DatabasePathway IDPathway Des.
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-114508Effects of PIP2 hydrolysis
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-76002Platelet activation, signaling and aggregation
kegghsa00561Glycerolipid metabolism - Homo sapiens (human)
kegghsa00564Glycerophospholipid metabolism - Homo sapiens (human)
kegghsa04070Phosphatidylinositol signaling system - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD474Avrainvillamide1
iGMDRD513BML-2592
iGMDRD255SB2250025
iGMDRD187BRD98761
iGMDRD52Rotenone2
iGMDRD885Compound 1106
iGMDRD399Selumetinib1
iGMDRD730Kahalalide F1
iGMDRD188Piperlongumine8
iGMDRD562Navitoclax7
iGMDRD506Fedratinib1
iGMDRD888Compound 443
iGMDRD577BIX012944
iGMDRD64Parbendazole2
iGMDRD60Quinoclamine7
iGMDRD451Serdemetan2
iGMDRD356PNU-746541
iGMDRD268Cerulenin2
iGMDRD210AC556491
iGMDRD126Tipifarnib4
iGMDRD670ML 2103
iGMDRD781Sirolimus2
iGMDRD494Neopeltolide5
iGMDRD446LY 21832401
iGMDRD193Fqi12
iGMDRD152179324-69-76
iGMDRD163all trans Retinoic Acid2
iGMDRD316N9-Isopropyl-olomoucine2
iGMDRD280CYTOCHALASIN B3
iGMDRD297Austocystin D2
iGMDRD202Curcumin2
iGMDRD251ML1623
iGMDRD5Tyrphostin AG 14783
iGMDRD434BMS-5369244
iGMDRD289Parthenolide2
iGMDRD77Itraconazole2
iGMDRD871BRD63686
iGMDRD329Merck605
iGMDRD662JQ-13
iGMDRD263AACOCF33
iGMDRD552AZD-17753
iGMDRD886Compound 1541A2
iGMDRD353PD03259011
iGMDRD330BRD41323
iGMDRD486Tosedostat2
iGMDRD84Lovastatin acid1
iGMDRD607Ubistatin B2
iGMDRD424Tamatinib1
iGMDRD150RITA3
iGMDRD701NVP-AUY9222
iGMDRD85Ursolic acid5
iGMDRD314Tanespimycin2
iGMDRD123Isoevodiamine1
iGMDRD945ML2144
iGMDRD132(-)-gallocatechin-3-O-gallate1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DGKB

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