DGKB
Summary: Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| diacylglycerol kinase beta | MIM:604070 | Ensembl:ENSG00000136267 | HGNC:HGNC:2850 | PA27311 | 7p21.2 |
Gene Categories:
KINASEGO terms in DGKB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003951 | NAD+ kinase activity |
| MF | IDA | GO:0004143 | diacylglycerol kinase activity |
| MF | TAS | GO:0004143 | diacylglycerol kinase activity |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IEA | GO:0005524 | ATP binding |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005886 | plasma membrane |
| BP | IEA | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0030168 | platelet activation |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0046486 | glycerolipid metabolic process |
| BP | IDA | GO:0046834 | lipid phosphorylation |
Gene expression in normal tissue: DGKB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DGKB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114508 | Effects of PIP2 hydrolysis |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| kegg | hsa00561 | Glycerolipid metabolism - Homo sapiens (human) |
| kegg | hsa00564 | Glycerophospholipid metabolism - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD255 | SB225002 | 5 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD885 | Compound 110 | 6 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD730 | Kahalalide F | 1 |
| iGMDRD188 | Piperlongumine | 8 |
| iGMDRD562 | Navitoclax | 7 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD60 | Quinoclamine | 7 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD494 | Neopeltolide | 5 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD152 | 179324-69-7 | 6 |
| iGMDRD163 | all trans Retinoic Acid | 2 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD329 | Merck60 | 5 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD263 | AACOCF3 | 3 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD486 | Tosedostat | 2 |
| iGMDRD84 | Lovastatin acid | 1 |
| iGMDRD607 | Ubistatin B | 2 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD150 | RITA | 3 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD85 | Ursolic acid | 5 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD945 | ML214 | 4 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DGKB
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