Summary: The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008].

growth hormone 1MIM:139250Ensembl:ENSG00000259384HGNC:HGNC:4261PA17117q23.3

GO terms in GH1

Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIDAGO:0005615extracellular space
CCTASGO:0031904endosome lumen
CCIDAGO:0070195growth hormone receptor complex
BPIDAGO:0002092positive regulation of receptor internalization
BPIEAGO:0010469regulation of signaling receptor activity
BPIDAGO:0010536positive regulation of activation of Janus kinase activity
BPIDAGO:0010828positive regulation of glucose transmembrane transport
BPIDAGO:0014068positive regulation of phosphatidylinositol 3-kinase signaling
BPIBAGO:0031667response to nutrient levels
BPIDAGO:0032355response to estradiol
BPIDAGO:0040018positive regulation of multicellular organism growth
BPIMPGO:0040018positive regulation of multicellular organism growth
BPIBAGO:0042531positive regulation of tyrosine phosphorylation of STAT protein
BPIDAGO:0042531positive regulation of tyrosine phosphorylation of STAT protein
BPTASGO:0043406positive regulation of MAP kinase activity
BPIDAGO:0043568positive regulation of insulin-like growth factor receptor signaling pathway
BPIBAGO:0045927positive regulation of growth
BPIBAGO:0046427positive regulation of JAK-STAT cascade
BPIDAGO:0046427positive regulation of JAK-STAT cascade
BPIBAGO:0048513animal organ development
BPIBAGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPIDAGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPIBAGO:0060396growth hormone receptor signaling pathway
BPIDAGO:0060396growth hormone receptor signaling pathway
BPTASGO:0060397JAK-STAT cascade involved in growth hormone signaling pathway
BPIDAGO:0070977bone maturation
MFIBAGO:0005131growth hormone receptor binding
MFIDAGO:0005131growth hormone receptor binding
MFIPIGO:0005131growth hormone receptor binding
MFIDAGO:0005148prolactin receptor binding
MFIPIGO:0005148prolactin receptor binding
MFIBAGO:0005179hormone activity
MFIEAGO:0005179hormone activity
MFIPIGO:0005515protein binding
MFIBAGO:0008083growth factor activity
MFIPIGO:0008083growth factor activity
MFIEAGO:0046872metal ion binding
MFIBAGO:0070186growth hormone activity

Gene expression in normal tissue: GH1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GH1

DatabasePathway IDPathway Des.
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP474Endochondral Ossification
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
biocartaaktpathwayakt signaling pathway
biocartaeif4pathwayregulation of eif-4e and p70s6 kinase
biocartaghpathwaygrowth hormone signaling pathway
biocartamtorpathwaymtor signaling pathway
biocartatffpathwaytrefoil factors initiate mucosal healing
reactomeR-HSA-1170546Prolactin receptor signaling
reactomeR-HSA-1170546Prolactin receptor signaling
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-2980736Peptide hormone metabolism
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-422085Synthesis, secretion, and deacylation of Ghrelin
reactomeR-HSA-982772Growth hormone receptor signaling
reactomeR-HSA-982772Growth hormone receptor signaling

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD889Compound 7d-cis3
iGMDRD446LY 21832403
iGMDRD341Triacsin c3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GH1