GH1


Summary: The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:139250
PHARMGKB IDPA171
Map Location17q23.3

GO terms in GH1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005576 extracellular region
CC IBA GO:0005615 extracellular space
CC IDA GO:0005615 extracellular space
CC TAS GO:0031904 endosome lumen
CC IDA GO:0070195 growth hormone receptor complex
BP IDA GO:0002092 positive regulation of receptor internalization
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Gene expression in normal tissue: GH1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GH1


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Database
Pathway ID
Pathway Des.
wikipathways WP236 Adipogenesis
wikipathways WP4172 PI3K-Akt Signaling Pathway
wikipathways WP474 Endochondral Ossification
kegg hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegg hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegg hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD137 Indisulam 6
iGMDRD474 Avrainvillamide 3
iGMDRD121 GMX1778 3
iGMDRD6 AM-580 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GH1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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