PI4K2B

Summary: This gene encodes a member of the type II PI4 kinase protein family. The encoded protein is primarily cytosolic and contributes to overall PI4-kinase activity along with other protein family members. This protein is involved in early T cell activation. [provided by RefSeq, Dec 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namephosphatidylinositol 4-kinase type 2 beta
OMIM IDMIM:612101
Ensembl IDEnsembl:ENSG00000281028
HGNC IDHGNC:HGNC:18215
PHARMGKB IDPA142671173
Map Location4p15.2

GO terms in PI4K2B


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0004430 1-phosphatidylinositol 4-kinase activity
MF TAS GO:0004430 1-phosphatidylinositol 4-kinase activity
MF IEA GO:0005524 ATP binding
CC IBA GO:0005768 endosome
CC IBA GO:0005802 trans-Golgi network
CC TAS GO:0005829 cytosol
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Gene expression in normal tissue: PI4K2B

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 46BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 7

Gene-drug pathway distribution

undefined19Genome integrity1

Pathways in PI4K2B


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Database
Pathway ID
Pathway Des.
kegg hsa00562 Inositol phosphate metabolism - Homo sapiens (human)
kegg hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human)
humancyc PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis
humancyc PWY-6352 3-phosphoinositide biosynthesis
humancyc PWY-6371 superpathway of inositol phosphate compounds
reactome R-HSA-1430728 Metabolism
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD901 ELCPK 3
iGMDRD679 Bistramide A 2
iGMDRD280 CYTOCHALASIN B 3
iGMDRD639 YK 4-279 3
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Gene in drug-gene network: Network Plot

DSTYKDSTYKFLI1FLI1BRSK2BRSK2ADGRG4ADGRG4EPHA3EPHA3ERBB4ERBB4NYNRINNYNRINNOVA1NOVA1SMAD4SMAD4HOXD13HOXD13CUBNCUBNEPHA5EPHA5CNTN6CNTN6ELCPKELCPKAIFM3AIFM3MAP3K20MAP3K20FGRFGRCYLDCYLDLGR5LGR5RXRARXRACTDSPLCTDSPLLAMA1LAMA1ALKALKATMATMCICCICTRIP13TRIP13PMLPMLADAMTS18ADAMTS18GDNFGDNFARFGEF1ARFGEF1MYCMYCPTENPTENNTRK2NTRK2CAMK4CAMK4Bistramide ABistramide AADAMTS20ADAMTS20MYCLMYCLIKZF3IKZF3STK40STK40PIP5K1BPIP5K1BMFSD2AMFSD2ACMC4CMC4RPTORRPTORPHKG1PHKG1FRKFRKGRIA3GRIA3CYTOCHALASIN BCYTOCHALASIN BBRCA2BRCA2CLTCCLTCYK 4-279YK 4-279KRASKRASPRKG2PRKG2SMARCA4SMARCA4TWF1TWF1MRE11MRE11GLG1GLG1RGL2RGL2MAP4K2MAP4K2PTCH1PTCH1MAP2K7MAP2K7PPP1R3APPP1R3ASTAT6STAT6RB1RB1TNNTNNGRIN2BGRIN2BKinetin ribosideKinetin ribosideAFDNAFDNNLRP3NLRP3USP6USP6TGTGLDLRLDLRTFE3TFE3MTUS2MTUS2NSD3NSD3HDAC8HDAC8Triacsin cTriacsin cMSH6MSH6LRP2LRP2COL14A1COL14A1BRIP1BRIP1SIK3SIK3CACNB2CACNB2ZFP69BZFP69BSOS1SOS1CNTRLCNTRLALPK2ALPK2GRK7GRK7JAG1JAG1LY 2183240LY 2183240SERPINA2SERPINA2CREBBPCREBBPTMEM74TMEM74MSH3MSH3BRCA1BRCA1BRAFBRAFTANKTANKDHFRDHFRALPK1ALPK1OlaparibOlaparibESR2ESR2ITGB6ITGB6KPNA5KPNA5NANOS3NANOS3PIKFYVEPIKFYVECSNK1A1CSNK1A1CHN1CHN1FHITFHITMAP3K9MAP3K9PRKG1PRKG1PDGFRAPDGFRAOLFM4OLFM4GHRGHRABT737ABT737PXDNPXDNAXIN2AXIN2EGFREGFRFGFR4FGFR4LRP1BLRP1BSTAG3STAG3nutlin 3nutlin 3CTSSCTSSCSNK1DCSNK1DCYP2B6CYP2B6Compound 7d-cisCompound 7d-cisSTAT3STAT3RBM15RBM15LMTK2LMTK2TAF15TAF15ADCK2ADCK2SACSSACSTRIM33TRIM33TipifarnibTipifarnibNKX2-1NKX2-1GUCY1A2GUCY1A2AMER1AMER1PHF3PHF3PRAMEPRAMEEGFEGFMBIPMBIPNTRK3NTRK3Compound 1541ACompound 1541AADKADKPPARDPPARDPKHD1PKHD1CASP1CASP1ITGA10ITGA10YAP1YAP1IL3IL3DDX1DDX1MLLT1MLLT1PDPK1PDPK1BIX01294BIX01294COPS5COPS5ZMYM2ZMYM2RASA3RASA3ARHGAP29ARHGAP29CYP17A1CYP17A1CCNE1CCNE1AURKCAURKCMAP3K1MAP3K1ADHFE1ADHFE1TTBK1TTBK1GPHNGPHNJAK2JAK2MAPK14MAPK14IFNA2IFNA2MST-312MST-312PROCPROCKahalalide FKahalalide FLRRC7LRRC7MIEN1MIEN1NOTCH1NOTCH1EP300EP300OBSCNOBSCNORMDL3ORMDL3IL6STIL6STKALRNKALRNCSF3CSF3RORARORAATP13A5ATP13A5ZNF331ZNF331TAF1LTAF1LELAVL1ELAVL1SB225002SB225002C1QTNF12C1QTNF12TPRTPRMAP2K3MAP2K3TRAF6TRAF6NAV3NAV3TYRO3TYRO3SPRY2SPRY2PRKCQPRKCQTNFRSF4TNFRSF4STK24STK24AvrainvillamideAvrainvillamideEPHA2EPHA2C1DC1DTNK2TNK2SIX4SIX4ADGRB1ADGRB1MGAMGAFLNCFLNCPIK3CGPIK3CGKITKITPIM3PIM3MYLKMYLKIndisulamIndisulamTTKTTKNUP210NUP210NUTM1NUTM1EPHA7EPHA7MAST4MAST4TEKTEKROBO2ROBO2HERC2HERC2TOX4TOX4GMX1778GMX1778PI4K2BPI4K2B

Gene-drug targets distribution

Gene Structure: PDB

Models in PI4K2B

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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