TP73


Summary: This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
tumor protein p73MIM:601990Ensembl:ENSG00000078900HGNC:HGNC:12003PA366841p36.32

GO terms in TP73


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIPIGO:0002039p53 binding
MFIDAGO:0003700DNA-binding transcription factor activity
MFIMPGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIPIGO:0008134transcription factor binding
MFIPIGO:0019901protein kinase binding
MFIPIGO:0042802identical protein binding
MFIDAGO:0044212transcription regulatory region DNA binding
MFIEAGO:0046872metal ion binding
MFIPIGO:0097371MDM2/MDM4 family protein binding
BPIEAGO:0000187activation of MAPK activity
BPIEAGO:0001822kidney development
BPTASGO:0006298mismatch repair
BPIEAGO:0006366transcription by RNA polymerase II
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIEAGO:0007050cell cycle arrest
BPIMPGO:0007346regulation of mitotic cell cycle
BPTASGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPIEAGO:0010243response to organonitrogen compound
BPIMPGO:0010468regulation of gene expression
BPIEAGO:0016032viral process
BPIEAGO:0042493response to drug
BPIDAGO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
BPTASGO:0042981regulation of apoptotic process
BPIEAGO:0045665negative regulation of neuron differentiation
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048714positive regulation of oligodendrocyte differentiation
BPIEAGO:0051262protein tetramerization
BPIMPGO:0060044negative regulation of cardiac muscle cell proliferation
BPIDAGO:0071158positive regulation of cell cycle arrest
BPTASGO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
BPTASGO:1901796regulation of signal transduction by p53 class mediator
BPTASGO:1902036regulation of hematopoietic stem cell differentiation
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIEAGO:0005739mitochondrion
CCIDAGO:0005794Golgi apparatus
CCTASGO:0005829cytosol
CCIDAGO:0030054cell junction
CCIDAGO:0043231intracellular membrane-bounded organelle

Gene expression in normal tissue: TP73

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TP73


DatabasePathway IDPathway Des.
pide2f_pathwayE2F transcription factor network
pidp53downstreampathwayDirect p53 effectors
pidp73pathwayp73 transcription factor network
netpathPathway_Alpha6Beta4IntegrinAlpha6Beta4Integrin
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
kegghsa04115p53 signaling pathway - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
wikipathwaysWP1742TP53 Network
wikipathwaysWP2516ATM Signaling Pathway
wikipathwaysWP254Apoptosis
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
wikipathwaysWP710DNA Damage Response (only ATM dependent)
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-109606Intrinsic Pathway for Apoptosis
reactomeR-HSA-114452Activation of BH3-only proteins
reactomeR-HSA-139915Activation of PUMA and translocation to mitochondria
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5633008TP53 Regulates Transcription of Cell Death Genes
reactomeR-HSA-6803204TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
reactomeR-HSA-6803205TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
reactomeR-HSA-6803207TP53 Regulates Transcription of Caspase Activators and Caspases
reactomeR-HSA-6803211TP53 Regulates Transcription of Death Receptors and Ligands
reactomeR-HSA-6804759Regulation of TP53 Activity through Association with Co-factors
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCs
biocartaatmpathwayatm signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD512nutlin 33
iGMDRD607Ubistatin B3
iGMDRD330BRD41323
iGMDRD494Neopeltolide3
iGMDRD427ABT7373
iGMDRD424Tamatinib3
iGMDRD57Chloropentafluorobenzene2
iGMDRD280CYTOCHALASIN B2
iGMDRD474Avrainvillamide1
iGMDRD52Rotenone3
iGMDRD171Pemetrexed3
iGMDRD662JQ-13
iGMDRD269Purmorphamine3
iGMDRD398Sepantronium3
iGMDRD286Nsc 6328391
iGMDRD100Zebularine3
iGMDRD300Tozasertib4
iGMDRD886Compound 1541A3
iGMDRD147Prima-11

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TP73

​​​​