TP73
Summary: This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tumor protein p73 | MIM:601990 | Ensembl:ENSG00000078900 | HGNC:HGNC:12003 | PA36684 | 1p36.32 |
GO terms in TP73
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IPI | GO:0002039 | p53 binding |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IMP | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IPI | GO:0097371 | MDM2/MDM4 family protein binding |
| BP | IEA | GO:0000187 | activation of MAPK activity |
| BP | IEA | GO:0001822 | kidney development |
| BP | TAS | GO:0006298 | mismatch repair |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IEA | GO:0007050 | cell cycle arrest |
| BP | IMP | GO:0007346 | regulation of mitotic cell cycle |
| BP | TAS | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
| BP | IEA | GO:0010243 | response to organonitrogen compound |
| BP | IMP | GO:0010468 | regulation of gene expression |
| BP | IEA | GO:0016032 | viral process |
| BP | IEA | GO:0042493 | response to drug |
| BP | IDA | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| BP | TAS | GO:0042981 | regulation of apoptotic process |
| BP | IEA | GO:0045665 | negative regulation of neuron differentiation |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048714 | positive regulation of oligodendrocyte differentiation |
| BP | IEA | GO:0051262 | protein tetramerization |
| BP | IMP | GO:0060044 | negative regulation of cardiac muscle cell proliferation |
| BP | IDA | GO:0071158 | positive regulation of cell cycle arrest |
| BP | TAS | GO:1900740 | positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| BP | TAS | GO:1901796 | regulation of signal transduction by p53 class mediator |
| BP | TAS | GO:1902036 | regulation of hematopoietic stem cell differentiation |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0030054 | cell junction |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
Gene expression in normal tissue: TP73
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TP73
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | e2f_pathway | E2F transcription factor network |
| pid | p53downstreampathway | Direct p53 effectors |
| pid | p73pathway | p73 transcription factor network |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| wikipathways | WP1742 | TP53 Network |
| wikipathways | WP2516 | ATM Signaling Pathway |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
| reactome | R-HSA-114452 | Activation of BH3-only proteins |
| reactome | R-HSA-139915 | Activation of PUMA and translocation to mitochondria |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes |
| reactome | R-HSA-6803204 | TP53 Regulates Transcription of Genes Involved in Cytochrome C Release |
| reactome | R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain |
| reactome | R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases |
| reactome | R-HSA-6803211 | TP53 Regulates Transcription of Death Receptors and Ligands |
| reactome | R-HSA-6804759 | Regulation of TP53 Activity through Association with Co-factors |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs |
| biocarta | atmpathway | atm signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD607 | Ubistatin B | 3 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD269 | Purmorphamine | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD300 | Tozasertib | 4 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD147 | Prima-1 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TP73
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.