RNASE1
Summary: This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ribonuclease A family member 1, pancreatic | MIM:180440 | Ensembl:ENSG00000129538 | HGNC:HGNC:10044 | PA34412 | 14q11.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in RNASE1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003676 | nucleic acid binding |
| MF | IBA | GO:0004519 | endonuclease activity |
| MF | IEA | GO:0004522 | ribonuclease A activity |
| MF | IBA | GO:0004540 | ribonuclease activity |
| MF | IDA | GO:0004540 | ribonuclease activity |
| MF | IPI | GO:0005515 | protein binding |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IDA | GO:0051607 | defense response to virus |
| BP | IDA | GO:0090501 | RNA phosphodiester bond hydrolysis |
| BP | IEA | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic |
Gene expression in normal tissue: RNASE1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RNASE1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD177 | Teniposide | 3 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD775 | NCGC00346967-01 | 1 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD614 | Dabrafenib | 1 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD596 | Vemurafenib | 1 |
| iGMDRD606 | COT Inhibitor-2 | 1 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD839 | BRAF inhibitor | 1 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD840 | BRAF inhibitors in BRAF mutant tumor | 1 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD389 | SB525334 | 1 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD255 | SB225002 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RNASE1
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