RNASE1
Summary: This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:180440 Ensembl IDEnsembl:ENSG00000129538 HGNC IDHGNC:HGNC:10044 PHARMGKB IDPA34412 Map Location14q11.2 | |||||
Gene Categories:
DRUGGABLE GENOMEGO terms in RNASE1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003676 | nucleic acid binding |
| MF | IBA | GO:0004519 | endonuclease activity |
| MF | IEA | GO:0004522 | ribonuclease A activity |
| MF | IBA | GO:0004540 | ribonuclease activity |
| MF | IDA | GO:0004540 | ribonuclease activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: RNASE1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RNASE1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RNASE1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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