PRKCE
Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase C epsilon | MIM:176975 | Ensembl:ENSG00000171132 | HGNC:HGNC:9401 | PA33765 | 2p21 |
GO terms in PRKCE
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0003785 | actin monomer binding |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004697 | protein kinase C activity |
| MF | TAS | GO:0004697 | protein kinase C activity |
| MF | IEA | GO:0004699 | calcium-independent protein kinase C activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IMP | GO:0008047 | enzyme activator activity |
| MF | IDA | GO:0019899 | enzyme binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IEA | GO:0030546 | receptor activator activity |
| MF | IEA | GO:0035276 | ethanol binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IEA | GO:0071889 | 14-3-3 protein binding |
| CC | IEA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | ISS | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005856 | cytoskeleton |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0048471 | perinuclear region of cytoplasm |
| CC | ISS | GO:0071944 | cell periphery |
| BP | IEA | GO:0002281 | macrophage activation involved in immune response |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IEA | GO:0007049 | cell cycle |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IMP | GO:0010634 | positive regulation of epithelial cell migration |
| BP | ISS | GO:0010763 | positive regulation of fibroblast migration |
| BP | IEA | GO:0010811 | positive regulation of cell-substrate adhesion |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | TAS | GO:0030168 | platelet activation |
| BP | ISS | GO:0030838 | positive regulation of actin filament polymerization |
| BP | IEA | GO:0031397 | negative regulation of protein ubiquitination |
| BP | ISS | GO:0031663 | lipopolysaccharide-mediated signaling pathway |
| BP | IEA | GO:0032024 | positive regulation of insulin secretion |
| BP | IEA | GO:0032230 | positive regulation of synaptic transmission, GABAergic |
| BP | IMP | GO:0032467 | positive regulation of cytokinesis |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IEA | GO:0035641 | locomotory exploration behavior |
| BP | ISS | GO:0035669 | TRAM-dependent toll-like receptor 4 signaling pathway |
| BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| BP | IEA | GO:0043085 | positive regulation of catalytic activity |
| BP | IEA | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0043278 | response to morphine |
| BP | IEA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IEA | GO:0050730 | regulation of peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0050996 | positive regulation of lipid catabolic process |
| BP | IEA | GO:0051209 | release of sequestered calcium ion into cytosol |
| BP | IEA | GO:0051279 | regulation of release of sequestered calcium ion into cytosol |
| BP | IEA | GO:0051301 | cell division |
| BP | IEA | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus |
| BP | IEA | GO:0070257 | positive regulation of mucus secretion |
| BP | IEA | GO:0071361 | cellular response to ethanol |
| BP | IEA | GO:0071380 | cellular response to prostaglandin E stimulus |
| BP | IEA | GO:0071456 | cellular response to hypoxia |
| BP | IMP | GO:0090303 | positive regulation of wound healing |
| BP | TAS | GO:1903078 | positive regulation of protein localization to plasma membrane |
| BP | IEA | GO:2000273 | positive regulation of signaling receptor activity |
| BP | TAS | GO:2000650 | negative regulation of sodium ion transmembrane transporter activity |
| BP | IMP | GO:2001031 | positive regulation of cellular glucuronidation |
Gene expression in normal tissue: PRKCE
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKCE
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | akapcentrosomepathway | protein kinase a at the centrosome |
| biocarta | flumazenilpathway | cardiac protection against ros |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | ptdinspathway | phosphoinositides and their downstream targets |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114508 | Effects of PIP2 hydrolysis |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1250196 | SHC1 events in ERBB2 signaling |
| reactome | R-HSA-1489509 | DAG and IP3 signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029485 | Role of phospholipids in phagocytosis |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-418597 | G alpha (z) signalling events |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| wikipathways | WP1528 | Physiological and Pathological Hypertrophy of the Heart |
| wikipathways | WP2012 | miRs in Muscle Cell Differentiation |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP35 | G Protein Signaling Pathways |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
| pharmgkb | PA165984799 | Diuretics Pathway, Pharmacodynamics |
| pharmgkb | PA2024 | Beta-agonist/Beta-blocker Pathway, Pharmacodynamics |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| pid | cd8tcrdownstreampathway | Downstream signaling in naïve CD8+ T cells |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | endothelinpathway | Endothelins |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | il8cxcr1_pathway | IL8- and CXCR1-mediated signaling events |
| pid | lpa4_pathway | LPA4-mediated signaling events |
| pid | lysophospholipid_pathway | LPA receptor mediated events |
| pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | ras_pathway | Regulation of Ras family activation |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| pid | txa2pathway | Thromboxane A2 receptor signaling |
| netpath | Pathway_Ghrelin | Ghrelin |
| netpath | Pathway_Leptin | Leptin |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04930 | Type II diabetes mellitus - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD341 | Triacsin c | 1 |
| iGMDRD154 | NSC23766 | 5 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD424 | Tamatinib | 5 |
| iGMDRD269 | Purmorphamine | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD300 | Tozasertib | 4 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD126 | Tipifarnib | 7 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD506 | Fedratinib | 5 |
| iGMDRD577 | BIX01294 | 7 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD444 | Tivantinib | 2 |
| iGMDRD60 | Quinoclamine | 6 |
| iGMDRD255 | SB225002 | 4 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD885 | Compound 110 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRKCE
CLASSFICATION
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