PRKCE


Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein kinase C epsilonMIM:176975Ensembl:ENSG00000171132HGNC:HGNC:9401PA337652p21

GO terms in PRKCE


Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0003785actin monomer binding
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004697protein kinase C activity
MFTASGO:0004697protein kinase C activity
MFIEAGO:0004699calcium-independent protein kinase C activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIMPGO:0008047enzyme activator activity
MFIDAGO:0019899enzyme binding
MFIPIGO:0019899enzyme binding
MFIEAGO:0030546receptor activator activity
MFIEAGO:0035276ethanol binding
MFIEAGO:0046872metal ion binding
MFIEAGO:007188914-3-3 protein binding
CCIEAGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCIEAGO:0005739mitochondrion
CCIDAGO:0005783endoplasmic reticulum
CCISSGO:0005794Golgi apparatus
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIEAGO:0005856cytoskeleton
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCISSGO:0048471perinuclear region of cytoplasm
CCISSGO:0071944cell periphery
BPIEAGO:0002281macrophage activation involved in immune response
BPIDAGO:0006468protein phosphorylation
BPTASGO:0006915apoptotic process
BPIEAGO:0007049cell cycle
BPIEAGO:0007155cell adhesion
BPTASGO:0007165signal transduction
BPIMPGO:0010634positive regulation of epithelial cell migration
BPISSGO:0010763positive regulation of fibroblast migration
BPIEAGO:0010811positive regulation of cell-substrate adhesion
BPIBAGO:0018105peptidyl-serine phosphorylation
BPIDAGO:0018105peptidyl-serine phosphorylation
BPTASGO:0030168platelet activation
BPISSGO:0030838positive regulation of actin filament polymerization
BPIEAGO:0031397negative regulation of protein ubiquitination
BPISSGO:0031663lipopolysaccharide-mediated signaling pathway
BPIEAGO:0032024positive regulation of insulin secretion
BPIEAGO:0032230positive regulation of synaptic transmission, GABAergic
BPIMPGO:0032467positive regulation of cytokinesis
BPIBAGO:0035556intracellular signal transduction
BPIEAGO:0035641locomotory exploration behavior
BPISSGO:0035669TRAM-dependent toll-like receptor 4 signaling pathway
BPTASGO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis
BPIEAGO:0043085positive regulation of catalytic activity
BPIEAGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0043278response to morphine
BPIEAGO:0043410positive regulation of MAPK cascade
BPIEAGO:0050730regulation of peptidyl-tyrosine phosphorylation
BPIEAGO:0050996positive regulation of lipid catabolic process
BPIEAGO:0051209release of sequestered calcium ion into cytosol
BPIEAGO:0051279regulation of release of sequestered calcium ion into cytosol
BPIEAGO:0051301cell division
BPIEAGO:0061178regulation of insulin secretion involved in cellular response to glucose stimulus
BPIEAGO:0070257positive regulation of mucus secretion
BPIEAGO:0071361cellular response to ethanol
BPIEAGO:0071380cellular response to prostaglandin E stimulus
BPIEAGO:0071456cellular response to hypoxia
BPIMPGO:0090303positive regulation of wound healing
BPTASGO:1903078positive regulation of protein localization to plasma membrane
BPIEAGO:2000273positive regulation of signaling receptor activity
BPTASGO:2000650negative regulation of sodium ion transmembrane transporter activity
BPIMPGO:2001031positive regulation of cellular glucuronidation

Gene expression in normal tissue: PRKCE

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRKCE


DatabasePathway IDPathway Des.
biocartaakapcentrosomepathwayprotein kinase a at the centrosome
biocartaflumazenilpathwaycardiac protection against ros
biocartakeratinocytepathwaykeratinocyte differentiation
biocartaptdinspathwayphosphoinositides and their downstream targets
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-114508Effects of PIP2 hydrolysis
reactomeR-HSA-1227986Signaling by ERBB2
reactomeR-HSA-1250196SHC1 events in ERBB2 signaling
reactomeR-HSA-1489509DAG and IP3 signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosis
reactomeR-HSA-2029485Role of phospholipids in phagocytosis
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-418597G alpha (z) signalling events
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
wikipathwaysWP1528Physiological and Pathological Hypertrophy of the Heart
wikipathwaysWP2012miRs in Muscle Cell Differentiation
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP35G Protein Signaling Pathways
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP536Calcium Regulation in the Cardiac Cell
pharmgkbPA165984799Diuretics Pathway, Pharmacodynamics
pharmgkbPA2024Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
pharmgkbPA2032VEGF Signaling Pathway
pidcd8tcrdownstreampathwayDownstream signaling in naïve CD8+ T cells
pidcd8tcrpathwayTCR signaling in naïve CD8+ T cells
pidcdc42_pathwayCDC42 signaling events
pidendothelinpathwayEndothelins
pidil2_1pathwayIL2-mediated signaling events
pidil8cxcr1_pathwayIL8- and CXCR1-mediated signaling events
pidlpa4_pathwayLPA4-mediated signaling events
pidlysophospholipid_pathwayLPA receptor mediated events
pidnfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidras_pathwayRegulation of Ras family activation
pidtcr_pathwayTCR signaling in naïve CD4+ T cells
pidtxa2pathwayThromboxane A2 receptor signaling
netpathPathway_GhrelinGhrelin
netpathPathway_LeptinLeptin
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04371Apelin signaling pathway - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)
kegghsa04666Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa04925Aldosterone synthesis and secretion - Homo sapiens (human)
kegghsa04930Type II diabetes mellitus - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD341Triacsin c1
iGMDRD154NSC237665
iGMDRD901ELCPK2
iGMDRD123Isoevodiamine3
iGMDRD177Teniposide3
iGMDRD424Tamatinib5
iGMDRD269Purmorphamine3
iGMDRD286Nsc 6328393
iGMDRD871BRD63683
iGMDRD322FK 8662
iGMDRD886Compound 1541A3
iGMDRD300Tozasertib4
iGMDRD137Indisulam3
iGMDRD158NSC1415403
iGMDRD434BMS-5369242
iGMDRD61Kinetin riboside2
iGMDRD446LY 21832403
iGMDRD679Bistramide A2
iGMDRD394BX-7953
iGMDRD579PF7503
iGMDRD126Tipifarnib7
iGMDRD427ABT7371
iGMDRD506Fedratinib5
iGMDRD577BIX012947
iGMDRD188Piperlongumine2
iGMDRD399Selumetinib3
iGMDRD524ISX-92
iGMDRD444Tivantinib2
iGMDRD60Quinoclamine6
iGMDRD255SB2250024
iGMDRD474Avrainvillamide1
iGMDRD885Compound 1102

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKCE

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