PRKCE
Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:176975 Ensembl IDEnsembl:ENSG00000171132 HGNC IDHGNC:HGNC:9401 PHARMGKB IDPA33765 Map Location2p21 | |||||
GO terms in PRKCE
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0003785 | actin monomer binding |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004697 | protein kinase C activity |
| MF | TAS | GO:0004697 | protein kinase C activity |
| MF | IEA | GO:0004699 | calcium-independent protein kinase C activity |
Gene expression in normal tissue: PRKCE
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKCE
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | akapcentrosomepathway | protein kinase a at the centrosome |
| biocarta | flumazenilpathway | cardiac protection against ros |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | ptdinspathway | phosphoinositides and their downstream targets |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114508 | Effects of PIP2 hydrolysis |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRKCE
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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