HOXD13
Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in this particular gene cause synpolydactyly. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| homeobox D13 | MIM:142989 | Ensembl:ENSG00000128714 | HGNC:HGNC:5136 | PA29410 | 2q31.1 |
GO terms in HOXD13
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IEA | GO:0001158 | enhancer sequence-specific DNA binding |
| MF | IMP | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | IEA | GO:0003682 | chromatin binding |
| MF | ISS | GO:0003700 | DNA-binding transcription factor activity |
| BP | IEA | GO:0001501 | skeletal system development |
| BP | TAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0009952 | anterior/posterior pattern specification |
| BP | IEA | GO:0030539 | male genitalia development |
| BP | IEA | GO:0033574 | response to testosterone |
| BP | IEA | GO:0042127 | regulation of cell proliferation |
| BP | IEA | GO:0042733 | embryonic digit morphogenesis |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048619 | embryonic hindgut morphogenesis |
| BP | IEA | GO:0060527 | prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis |
| BP | IEA | GO:0060571 | morphogenesis of an epithelial fold |
| BP | IEA | GO:0060602 | branch elongation of an epithelium |
| BP | IEA | GO:0060687 | regulation of branching involved in prostate gland morphogenesis |
| CC | IDA | GO:0005634 | nucleus |
Gene expression in normal tissue: HOXD13
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HOXD13
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD446 | LY 2183240 | 6 |
| iGMDRD152 | 179324-69-7 | 6 |
| iGMDRD61 | Kinetin riboside | 6 |
| iGMDRD193 | Fqi1 | 6 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD151 | CHM-1 | 6 |
| iGMDRD126 | Tipifarnib | 6 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD144 | NSC95397 | 9 |
| iGMDRD887 | Compound 23 citrate | 6 |
| iGMDRD188 | Piperlongumine | 9 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD577 | BIX01294 | 9 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD513 | BML-259 | 3 |
| iGMDRD255 | SB225002 | 4 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD260 | FQI-2 | 4 |
| iGMDRD782 | DC-45-A2 | 6 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD351 | GW843682X | 6 |
| iGMDRD698 | Neratinib | 6 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD123 | Isoevodiamine | 7 |
| iGMDRD901 | ELCPK | 6 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD486 | Tosedostat | 1 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD424 | Tamatinib | 5 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD263 | AACOCF3 | 5 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD300 | Tozasertib | 9 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD251 | ML162 | 6 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD103 | SN-38 | 1 |
| iGMDRD105 | Triptolide | 5 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD289 | Parthenolide | 6 |
| iGMDRD481 | Dactolisib | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HOXD13
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