HOXD13


Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in this particular gene cause synpolydactyly. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
homeobox D13MIM:142989Ensembl:ENSG00000128714HGNC:HGNC:5136PA294102q31.1

GO terms in HOXD13


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIEAGO:0001158enhancer sequence-specific DNA binding
MFIMPGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIDAGO:0003677DNA binding
MFIEAGO:0003682chromatin binding
MFISSGO:0003700DNA-binding transcription factor activity
BPIEAGO:0001501skeletal system development
BPTASGO:0006355regulation of transcription, DNA-templated
BPTASGO:0006366transcription by RNA polymerase II
BPTASGO:0007275multicellular organism development
BPIEAGO:0009952anterior/posterior pattern specification
BPIEAGO:0030539male genitalia development
BPIEAGO:0033574response to testosterone
BPIEAGO:0042127regulation of cell proliferation
BPIEAGO:0042733embryonic digit morphogenesis
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048619embryonic hindgut morphogenesis
BPIEAGO:0060527prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
BPIEAGO:0060571morphogenesis of an epithelial fold
BPIEAGO:0060602branch elongation of an epithelium
BPIEAGO:0060687regulation of branching involved in prostate gland morphogenesis
CCIDAGO:0005634nucleus

Gene expression in normal tissue: HOXD13

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HOXD13


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD446LY 21832406
iGMDRD152179324-69-76
iGMDRD61Kinetin riboside6
iGMDRD193Fqi16
iGMDRD394BX-7953
iGMDRD297Austocystin D3
iGMDRD151CHM-16
iGMDRD126Tipifarnib6
iGMDRD889Compound 7d-cis3
iGMDRD144NSC953979
iGMDRD887Compound 23 citrate6
iGMDRD188Piperlongumine9
iGMDRD780PP-303
iGMDRD562Navitoclax6
iGMDRD577BIX012949
iGMDRD506Fedratinib3
iGMDRD64Parbendazole6
iGMDRD451Serdemetan2
iGMDRD268Cerulenin2
iGMDRD23Gossypol3
iGMDRD138PX 123
iGMDRD474Avrainvillamide3
iGMDRD513BML-2593
iGMDRD255SB2250024
iGMDRD8024-methylfasudil3
iGMDRD260FQI-24
iGMDRD782DC-45-A26
iGMDRD187BRD98763
iGMDRD885Compound 1103
iGMDRD219Bax channel blocker3
iGMDRD237ABT-7513
iGMDRD351GW843682X6
iGMDRD698Neratinib6
iGMDRD57Chloropentafluorobenzene3
iGMDRD123Isoevodiamine7
iGMDRD901ELCPK6
iGMDRD945ML2146
iGMDRD883CIL55A3
iGMDRD486Tosedostat1
iGMDRD148Pifithrin-mu3
iGMDRD424Tamatinib5
iGMDRD116CD4373
iGMDRD701NVP-AUY9223
iGMDRD414MST-3123
iGMDRD871BRD63683
iGMDRD286Nsc 6328396
iGMDRD329Merck603
iGMDRD263AACOCF35
iGMDRD246NPC263
iGMDRD886Compound 1541A3
iGMDRD505Pevonedistat3
iGMDRD300Tozasertib9
iGMDRD121GMX17783
iGMDRD202Curcumin3
iGMDRD251ML1626
iGMDRD271Brefeldin A3
iGMDRD103SN-381
iGMDRD105Triptolide5
iGMDRD705Nakiterpiosin3
iGMDRD289Parthenolide6
iGMDRD481Dactolisib2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HOXD13

​​​​