DDX10
Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it may be involved in ribosome assembly. Fusion of this gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| DEAD-box helicase 10 | MIM:601235 | Ensembl:ENSG00000178105 | HGNC:HGNC:2735 | PA27200 | 11q22.3 |
GO terms in DDX10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | TAS | GO:0003724 | RNA helicase activity |
| MF | IEA | GO:0005524 | ATP binding |
| BP | IEA | GO:0097065 | anterior head development |
Gene expression in normal tissue: DDX10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DDX10
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD945 | ML214 | 3 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD718 | Pyrvinium pamoate | 3 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD121 | GMX1778 | 1 |
| iGMDRD474 | Avrainvillamide | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DDX10
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