DFFB
Summary: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. [provided by RefSeq, Sep 2013].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:601883 Ensembl IDEnsembl:ENSG00000169598 HGNC IDHGNC:HGNC:2773 PHARMGKB IDPA27255 Map Location1p36.32 |
GO terms in DFFB
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0004536 | deoxyribonuclease activity |
MF | IMP | GO:0004536 | deoxyribonuclease activity |
MF | IPI | GO:0005515 | protein binding |
MF | IPI | GO:0019899 | enzyme binding |
MF | IPI | GO:0019904 | protein domain specific binding |
MF | IMP | GO:0042802 | identical protein binding |
Gene expression in normal tissue: DFFB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DFFB
Database | Pathway ID | Pathway Des. |
---|---|---|
biocarta | caspasepathway | caspase cascade in apoptosis |
biocarta | deathpathway | induction of apoptosis through dr3 and dr4/5 death receptors |
biocarta | dnafragmentpathway | apoptotic dna-fragmentation and tissue homeostasis |
biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
biocarta | setpathway | granzyme a mediated apoptosis pathway |
reactome | R-HSA-109581 | Apoptosis |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in DFFB
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |