DFFB


Summary: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene but the biological validity of some of these variants has not been determined. [provided by RefSeq, Sep 2013].

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GO terms in DFFB


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0004536 deoxyribonuclease activity
MF IMP GO:0004536 deoxyribonuclease activity
MF IPI GO:0005515 protein binding
MF IPI GO:0019899 enzyme binding
MF IPI GO:0019904 protein domain specific binding
MF IMP GO:0042802 identical protein binding
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Gene expression in normal tissue: DFFB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DFFB


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Database
Pathway ID
Pathway Des.
biocarta caspasepathway caspase cascade in apoptosis
biocarta deathpathway induction of apoptosis through dr3 and dr4/5 death receptors
biocarta dnafragmentpathway apoptotic dna-fragmentation and tissue homeostasis
biocarta hivnefpathway hiv-1 nef: negative effector of fas and tnf
biocarta setpathway granzyme a mediated apoptosis pathway
reactome R-HSA-109581 Apoptosis
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD286 Nsc 632839 3
iGMDRD474 Avrainvillamide 1
iGMDRD780 PP-30 2
iGMDRD398 Sepantronium 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DFFB

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Model
Level
Reference ID
Tissue
Cancer
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No matching records found

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