CSNK1E


Summary: The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
casein kinase 1 epsilonMIM:600863Ensembl:ENSG00000213923HGNC:HGNC:2453PA2695322q13.1

GO terms in CSNK1E


Term TypeEvidence TypeGO Term IDGO Des.
MFHDAGO:0003723RNA binding
MFIDAGO:0004672protein kinase activity
MFISSGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
BPTASGO:0000086G2/M transition of mitotic cell cycle
BPTASGO:0006281DNA repair
BPIDAGO:0006468protein phosphorylation
BPISSGO:0006468protein phosphorylation
BPIBAGO:0006897endocytosis
BPTASGO:0007165signal transduction
BPTASGO:0010389regulation of G2/M transition of mitotic cell cycle
BPIBAGO:0018105peptidyl-serine phosphorylation
BPIDAGO:0018105peptidyl-serine phosphorylation
BPIDAGO:0032091negative regulation of protein binding
BPISSGO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process
BPISSGO:0032922circadian regulation of gene expression
BPISSGO:0042752regulation of circadian rhythm
BPIDAGO:0060070canonical Wnt signaling pathway
BPIGIGO:0060070canonical Wnt signaling pathway
BPIMPGO:0060070canonical Wnt signaling pathway
BPTASGO:0097711ciliary basal body-plasma membrane docking
BPIDAGO:1903827regulation of cellular protein localization
BPNASGO:1905426positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation
BPICGO:2000052positive regulation of non-canonical Wnt signaling pathway
CCIBAGO:0005634nucleus
CCISSGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol

Gene expression in normal tissue: CSNK1E

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CSNK1E


DatabasePathway IDPathway Des.
netpathPathway_WntWnt
pidbetacatenin_deg_pathwayDegradation of beta catenin
pidcircadianpathwayCircadian rhythm pathway
pidfoxopathwayFoxO family signaling
pidhedgehog_glipathwayHedgehog signaling events mediated by Gli proteins
pidp53regulationpathwayp53 pathway
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04340Hedgehog signaling pathway - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04392Hippo signaling pathway - multiple species - Homo sapiens (human)
kegghsa04710Circadian rhythm - Homo sapiens (human)
wikipathwaysWP3298Melatonin metabolism and effects
wikipathwaysWP363Wnt Signaling Pathway
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP4249Hedgehog Signaling Pathway
wikipathwaysWP428Wnt Signaling Pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1852241Organelle biogenesis and maintenance
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-201688WNT mediated activation of DVL
reactomeR-HSA-2565942Regulation of PLK1 Activity at G2/M Transition
reactomeR-HSA-380259Loss of Nlp from mitotic centrosomes
reactomeR-HSA-380270Recruitment of mitotic centrosome proteins and complexes
reactomeR-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosome
reactomeR-HSA-380287Centrosome maturation
reactomeR-HSA-380320Recruitment of NuMA to mitotic centrosomes
reactomeR-HSA-400253Circadian Clock
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-5617833Cilium Assembly
reactomeR-HSA-5620912Anchoring of the basal body to the plasma membrane
reactomeR-HSA-6791226Major pathway of rRNA processing in the nucleolus and cytosol
reactomeR-HSA-68877Mitotic Prometaphase
reactomeR-HSA-68886M Phase
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-72312rRNA processing
reactomeR-HSA-8854518AURKA Activation by TPX2
reactomeR-HSA-8868773rRNA processing in the nucleus and cytosol
reactomeR-HSA-8953854Metabolism of RNA

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD474Avrainvillamide3
iGMDRD782DC-45-A22
iGMDRD434BMS-5369243
iGMDRD885Compound 1103
iGMDRD871BRD63683
iGMDRD577BIX012943
iGMDRD64Parbendazole3
iGMDRD512nutlin 32
iGMDRD345Compound 10b [PMID: 11504634]3
iGMDRD150RITA1
iGMDRD79Gemcitabine1
iGMDRD193Fqi13
iGMDRD351GW843682X3
iGMDRD177Teniposide3
iGMDRD280CYTOCHALASIN B3
iGMDRD634SCHEMBL26080413

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CSNK1E

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