ARHGEF12
Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Rho guanine nucleotide exchange factor 12 | MIM:604763 | Ensembl:ENSG00000196914 | HGNC:HGNC:14193 | PA24969 | 11q23.3 |
GO terms in ARHGEF12
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0001664 | G-protein coupled receptor binding |
| MF | TAS | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
| MF | IEA | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
| BP | IDA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0007266 | Rho protein signal transduction |
| BP | IEA | GO:0035023 | regulation of Rho protein signal transduction |
| BP | TAS | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0016020 | membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: ARHGEF12
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARHGEF12
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | rhoa_reg_pathway | Regulation of RhoA activity |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-193648 | NRAGE signals death through JNK |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
| reactome | R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-400685 | Sema4D in semaphorin signaling |
| reactome | R-HSA-416482 | G alpha (12/13) signalling events |
| reactome | R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-73887 | Death Receptor Signalling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD484 | Pluripotin | 2 |
| iGMDRD150 | RITA | 7 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 5 |
| iGMDRD85 | Ursolic acid | 6 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD226 | ML006 | 4 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD888 | Compound 44 | 4 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD329 | Merck60 | 7 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD286 | Nsc 632839 | 1 |
| iGMDRD322 | FK 866 | 1 |
| iGMDRD886 | Compound 1541A | 6 |
| iGMDRD300 | Tozasertib | 5 |
| iGMDRD263 | AACOCF3 | 3 |
| iGMDRD246 | NPC26 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ARHGEF12
CLASSFICATION
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