ARHGEF12

Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameRho guanine nucleotide exchange factor 12
OMIM IDMIM:604763
Ensembl IDEnsembl:ENSG00000196914
HGNC IDHGNC:HGNC:14193
PHARMGKB IDPA24969
Map Location11q23.3

GO terms in ARHGEF12


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0001664 G-protein coupled receptor binding
MF TAS GO:0005085 guanyl-nucleotide exchange factor activity
MF TAS GO:0005089 Rho guanyl-nucleotide exchange factor activity
MF IEA GO:0005096 GTPase activator activity
MF IPI GO:0005515 protein binding
BP IDA GO:0007186 G-protein coupled receptor signaling pathway
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Gene expression in normal tissue: ARHGEF12

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 16LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 30undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 12undefinedtissue: undefined cancer: PANCAN model num: 36undefinedtissue: undefined cancer: SQUAMOUS_CELL_CARCINOMA model num: 4BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 3

Gene-drug pathway distribution

undefined23Apoptosis regulation2Mitosis1Metabolism1Chromatin other1Ferroptosis1Other, kinases1

Pathways in ARHGEF12


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Database
Pathway ID
Pathway Des.
pid rhoa_reg_pathway Regulation of RhoA activity
kegg hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
kegg hsa04360 Axon guidance - Homo sapiens (human)
kegg hsa04611 Platelet activation - Homo sapiens (human)
kegg hsa04625 C-type lectin receptor signaling pathway - Homo sapiens (human)
kegg hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD484 Pluripotin 2
iGMDRD150 RITA 7
iGMDRD427 ABT737 2
iGMDRD144 NSC95397 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ARHGEF12

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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