MYH10
Summary: This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| myosin heavy chain 10 | MIM:160776 | Ensembl:ENSG00000133026 | HGNC:HGNC:7568 | PA31366 | 17p13.1 |
Gene Categories:
CELL SURFACEGO terms in MYH10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000146 | microfilament motor activity |
| MF | IEA | GO:0003777 | microtubule motor activity |
| MF | NAS | GO:0003779 | actin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005516 | calmodulin binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | NAS | GO:0005524 | ATP binding |
| MF | IEA | GO:0008017 | microtubule binding |
| MF | IMP | GO:0016887 | ATPase activity |
| MF | IDA | GO:0030898 | actin-dependent ATPase activity |
| MF | IMP | GO:0030898 | actin-dependent ATPase activity |
| MF | IDA | GO:0035613 | RNA stem-loop binding |
| MF | IDA | GO:0043531 | ADP binding |
| MF | IDA | GO:0048027 | mRNA 5'-UTR binding |
| MF | IDA | GO:0051015 | actin filament binding |
| MF | IMP | GO:0051015 | actin filament binding |
| CC | IDA | GO:0001725 | stress fiber |
| CC | HDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005819 | spindle |
| CC | IMP | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IMP | GO:0005844 | polysome |
| CC | IEA | GO:0005903 | brush border |
| CC | IDA | GO:0005938 | cell cortex |
| CC | NAS | GO:0016459 | myosin complex |
| CC | IDA | GO:0016460 | myosin II complex |
| CC | IEA | GO:0030027 | lamellipodium |
| CC | IEA | GO:0030426 | growth cone |
| CC | IDA | GO:0030496 | midbody |
| CC | IEA | GO:0031594 | neuromuscular junction |
| CC | IDA | GO:0032154 | cleavage furrow |
| CC | IDA | GO:0042641 | actomyosin |
| CC | IEA | GO:0043025 | neuronal cell body |
| CC | IEA | GO:0043197 | dendritic spine |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0097513 | myosin II filament |
| BP | IDA | GO:0000281 | mitotic cytokinesis |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IEA | GO:0001764 | neuron migration |
| BP | IEA | GO:0001778 | plasma membrane repair |
| BP | IEA | GO:0003279 | cardiac septum development |
| BP | IEA | GO:0006887 | exocytosis |
| BP | IEA | GO:0006930 | substrate-dependent cell migration, cell extension |
| BP | IEA | GO:0007018 | microtubule-based movement |
| BP | IEA | GO:0007097 | nuclear migration |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | IEA | GO:0007411 | axon guidance |
| BP | IEA | GO:0007512 | adult heart development |
| BP | IEA | GO:0008283 | cell proliferation |
| BP | IEA | GO:0008360 | regulation of cell shape |
| BP | IEA | GO:0021592 | fourth ventricle development |
| BP | IEA | GO:0021670 | lateral ventricle development |
| BP | IEA | GO:0021678 | third ventricle development |
| BP | IEA | GO:0021680 | cerebellar Purkinje cell layer development |
| BP | IDA | GO:0030048 | actin filament-based movement |
| BP | IMP | GO:0031032 | actomyosin structure organization |
| BP | IEA | GO:0035904 | aorta development |
| BP | IMP | GO:0050714 | positive regulation of protein secretion |
| BP | IEA | GO:0050885 | neuromuscular process controlling balance |
| BP | IEA | GO:0055003 | cardiac myofibril assembly |
| BP | IEA | GO:0055015 | ventricular cardiac muscle cell development |
| BP | IEA | GO:0060041 | retina development in camera-type eye |
| BP | IEA | GO:0060976 | coronary vasculature development |
| BP | IEA | GO:0098885 | modification of postsynaptic actin cytoskeleton |
Gene expression in normal tissue: MYH10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MYH10
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-400685 | Sema4D in semaphorin signaling |
| reactome | R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-5625740 | RHO GTPases activate PKNs |
| reactome | R-HSA-5625900 | RHO GTPases activate CIT |
| reactome | R-HSA-5627117 | RHO GTPases Activate ROCKs |
| reactome | R-HSA-5627123 | RHO GTPases activate PAKs |
| reactome | R-HSA-5627123 | RHO GTPases activate PAKs |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD219 | Bax channel blocker | 5 |
| iGMDRD698 | Neratinib | 6 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD882 | CIL41 | 3 |
| iGMDRD871 | BRD6368 | 5 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD480 | KU0060648 | 3 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD318 | PAC-1 | 5 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD782 | DC-45-A2 | 6 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD6 | AM-580 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MYH10
CLASSFICATION
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