TNFRSF1A
Summary: This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq, Sep 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TNF receptor superfamily member 1A | MIM:191190 | Ensembl:ENSG00000067182 | HGNC:HGNC:11916 | PA36609 | 12p13.31 |
GO terms in TNFRSF1A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005031 | tumor necrosis factor-activated receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IBA | GO:0043120 | tumor necrosis factor binding |
| BP | ISS | GO:0003176 | aortic valve development |
| BP | ISS | GO:0003177 | pulmonary valve development |
| BP | ISS | GO:0003332 | negative regulation of extracellular matrix constituent secretion |
| BP | IEA | GO:0006693 | prostaglandin metabolic process |
| BP | ISS | GO:0006954 | inflammatory response |
| BP | TAS | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | TAS | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IEA | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
| BP | IEA | GO:0010614 | negative regulation of cardiac muscle hypertrophy |
| BP | TAS | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway |
| BP | IEA | GO:0016032 | viral process |
| BP | ISS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IMP | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | TAS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | IMP | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein |
| BP | IEA | GO:0042742 | defense response to bacterium |
| BP | IEP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0050728 | negative regulation of inflammatory response |
| BP | ISS | GO:0050729 | positive regulation of inflammatory response |
| BP | IEP | GO:0071260 | cellular response to mechanical stimulus |
| BP | TAS | GO:0071550 | death-inducing signaling complex assembly |
| BP | IMP | GO:0072659 | protein localization to plasma membrane |
| BP | ISS | GO:1902339 | positive regulation of apoptotic process involved in morphogenesis |
| BP | IMP | GO:1903140 | regulation of establishment of endothelial barrier |
| BP | TAS | GO:2000304 | positive regulation of ceramide biosynthetic process |
| CC | IDA | GO:0000139 | Golgi membrane |
| CC | NAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IBA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0009986 | cell surface |
| CC | IDA | GO:0043235 | receptor complex |
| CC | IDA | GO:0045121 | membrane raft |
Gene expression in normal tissue: TNFRSF1A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNFRSF1A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP2059 | Alzheimers Disease |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2447 | Amyotrophic lateral sclerosis (ALS) |
| wikipathways | WP2513 | Nanoparticle triggered regulated necrosis |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| wikipathways | WP3617 | Photodynamic therapy-induced NF-kB survival signaling |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP384 | Apoptosis Modulation by HSP70 |
| wikipathways | WP3850 | Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling |
| wikipathways | WP4063 | Interleukin-10 signaling |
| wikipathways | WP453 | Inflammatory Response Pathway |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | ceramide_pathway | Ceramide signaling pathway |
| pid | hdac_classi_pathway | Signaling events mediated by HDAC Class I |
| pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| pid | nfkappabcanonicalpathway | Canonical NF-kappaB pathway |
| pid | tnfpathway | TNF receptor signaling pathway |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04215 | Apoptosis - multiple species - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| kegg | hsa05014 | Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| biocarta | ceramidepathway | ceramide signaling pathway |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | nfkbpathway | nf-kb signaling pathway |
| biocarta | soddpathway | sodd/tnfr1 signaling pathway |
| biocarta | stresspathway | tnf/stress related signaling |
| biocarta | tnfr1pathway | tnfr1 signaling pathway |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-5357786 | TNFR1-induced proapoptotic signaling |
| reactome | R-HSA-5357905 | Regulation of TNFR1 signaling |
| reactome | R-HSA-5357956 | TNFR1-induced NFkappaB signaling pathway |
| reactome | R-HSA-5626978 | TNFR1-mediated ceramide production |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5669034 | TNFs bind their physiological receptors |
| reactome | R-HSA-6783783 | Interleukin-10 signaling |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-75893 | TNF signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD872 | BRD7137 | 1 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD255 | SB225002 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TNFRSF1A
CLASSFICATION
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