RPS6KB1
Summary: This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ribosomal protein S6 kinase B1 | MIM:608938 | Ensembl:ENSG00000108443 | HGNC:HGNC:10436 | PA34851 | 17q23.1 |
GO terms in RPS6KB1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IEA | GO:0005741 | mitochondrial outer membrane |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0009986 | cell surface |
| CC | IEA | GO:0030054 | cell junction |
| CC | IEA | GO:0043005 | neuron projection |
| CC | IEA | GO:0045202 | synapse |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| BP | IMP | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | IEA | GO:0001662 | behavioral fear response |
| BP | IEA | GO:0003009 | skeletal muscle contraction |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0007281 | germ cell development |
| BP | IEA | GO:0007568 | aging |
| BP | IEA | GO:0007584 | response to nutrient |
| BP | IEA | GO:0007616 | long-term memory |
| BP | IEA | GO:0009408 | response to heat |
| BP | IEA | GO:0009611 | response to wounding |
| BP | IEA | GO:0009612 | response to mechanical stimulus |
| BP | IEA | GO:0009749 | response to glucose |
| BP | IEA | GO:0014732 | skeletal muscle atrophy |
| BP | IEA | GO:0014878 | response to electrical stimulus involved in regulation of muscle adaptation |
| BP | IEA | GO:0014911 | positive regulation of smooth muscle cell migration |
| BP | IEA | GO:0016477 | cell migration |
| BP | IMP | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0031929 | TOR signaling |
| BP | IMP | GO:0031929 | TOR signaling |
| BP | IEA | GO:0032496 | response to lipopolysaccharide |
| BP | IBA | GO:0032869 | cellular response to insulin stimulus |
| BP | IEA | GO:0032869 | cellular response to insulin stimulus |
| BP | IEA | GO:0033574 | response to testosterone |
| BP | IEA | GO:0033762 | response to glucagon |
| BP | IEA | GO:0034612 | response to tumor necrosis factor |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0043201 | response to leucine |
| BP | IEA | GO:0043491 | protein kinase B signaling |
| BP | ISS | GO:0044539 | long-chain fatty acid import |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | IMP | GO:0045727 | positive regulation of translation |
| BP | IMP | GO:0045931 | positive regulation of mitotic cell cycle |
| BP | IBA | GO:0045948 | positive regulation of translational initiation |
| BP | IMP | GO:0045948 | positive regulation of translational initiation |
| BP | IEA | GO:0046324 | regulation of glucose import |
| BP | IMP | GO:0046627 | negative regulation of insulin receptor signaling pathway |
| BP | TAS | GO:0048015 | phosphatidylinositol-mediated signaling |
| BP | IEA | GO:0048633 | positive regulation of skeletal muscle tissue growth |
| BP | IEA | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| BP | IEA | GO:0071346 | cellular response to interferon-gamma |
| BP | IDA | GO:0071363 | cellular response to growth factor stimulus |
| BP | IEA | GO:0071549 | cellular response to dexamethasone stimulus |
| BP | IEA | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004711 | ribosomal protein S6 kinase activity |
| MF | IEA | GO:0004711 | ribosomal protein S6 kinase activity |
| MF | IDA | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0016301 | kinase activity |
| MF | IEA | GO:0030165 | PDZ domain binding |
| MF | IEA | GO:0042277 | peptide binding |
| MF | IEA | GO:0042802 | identical protein binding |
| MF | IEA | GO:0051721 | protein phosphatase 2A binding |
Gene expression in normal tissue: RPS6KB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RPS6KB1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | ctcfpathway | ctcf: first multivalent nuclear factor |
| biocarta | eif4pathway | regulation of eif-4e and p70s6 kinase |
| biocarta | igf1mtorpathway | skeletal muscle hypertrophy is regulated via akt-mtor pathway |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| biocarta | il4pathway | il 4 signaling pathway |
| biocarta | mtorpathway | mtor signaling pathway |
| biocarta | nfatpathway | nfat and hypertrophy of the heart |
| biocarta | ptdinspathway | phosphoinositides and their downstream targets |
| biocarta | rac1pathway | rac1 cell motility signaling pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-165159 | mTOR signalling |
| reactome | R-HSA-166208 | mTORC1-mediated signalling |
| wikipathways | WP127 | IL-5 Signaling Pathway |
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
| wikipathways | WP1471 | Target Of Rapamycin (TOR) Signaling |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2035 | Follicle Stimulating Hormone (FSH) signaling pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP364 | IL-6 signaling pathway |
| wikipathways | WP3676 | BDNF-TrkB Signaling |
| wikipathways | WP3850 | Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP477 | Cytoplasmic Ribosomal Proteins |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP49 | IL-2 Signaling Pathway |
| wikipathways | WP524 | G13 Signaling Pathway |
| wikipathways | WP585 | Interferon type I signaling pathways |
| wikipathways | WP673 | ErbB Signaling Pathway |
| smpdb | SMP00682 | Leucine Stimulation on Insulin Signaling |
| pid | a6b1_a6b4_integrin_pathway | a6b1 and a6b4 Integrin signaling |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | avb3_integrin_pathway | Integrins in angiogenesis |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | igf1_pathway | IGF1 pathway |
| pid | il2_pi3kpathway | IL2 signaling events mediated by PI3K |
| pid | il4_2pathway | IL4-mediated signaling events |
| pid | insulin_pathway | Insulin Pathway |
| pid | kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| pid | mtor_4pathway | mTOR signaling pathway |
| pid | rxr_vdr_pathway | RXR and RAR heterodimerization with other nuclear receptor |
| pid | telomerasepathway | Regulation of Telomerase |
| pid | tgfbrpathway | TGF-beta receptor signaling |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| kegg | hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| kegg | hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_TCR | TCR |
| netpath | Pathway_TNFalpha | TNFalpha |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD872 | BRD7137 | 1 |
| iGMDRD577 | BIX01294 | 1 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD945 | ML214 | 5 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD150 | RITA | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RPS6KB1
CLASSFICATION
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