RPS6KB1
Summary: This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:608938 Ensembl IDEnsembl:ENSG00000108443 HGNC IDHGNC:HGNC:10436 PHARMGKB IDPA34851 Map Location17q23.1 | |||||
GO terms in RPS6KB1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IEA | GO:0005741 | mitochondrial outer membrane |
| CC | TAS | GO:0005829 | cytosol |
Gene expression in normal tissue: RPS6KB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RPS6KB1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | ctcfpathway | ctcf: first multivalent nuclear factor |
| biocarta | eif4pathway | regulation of eif-4e and p70s6 kinase |
| biocarta | igf1mtorpathway | skeletal muscle hypertrophy is regulated via akt-mtor pathway |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| biocarta | il4pathway | il 4 signaling pathway |
| biocarta | mtorpathway | mtor signaling pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RPS6KB1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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