WNT1
Summary: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Wnt family member 1 | MIM:164820 | Ensembl:ENSG00000125084 | HGNC:HGNC:12774 | PA37376 | 12q13.12 |
GO terms in WNT1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005109 | frizzled binding |
| MF | IC | GO:0005109 | frizzled binding |
| MF | NAS | GO:0005109 | frizzled binding |
| MF | ISS | GO:0005125 | cytokine activity |
| MF | TAS | GO:0016015 | morphogen activity |
| MF | IEA | GO:0019904 | protein domain specific binding |
| MF | IDA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IC | GO:0048018 | receptor ligand activity |
| MF | IDA | GO:0048018 | receptor ligand activity |
| MF | NAS | GO:0048018 | receptor ligand activity |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | TAS | GO:0005796 | Golgi lumen |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0009986 | cell surface |
| CC | TAS | GO:0030666 | endocytic vesicle membrane |
| CC | TAS | GO:0070062 | extracellular exosome |
| BP | ISS | GO:0000578 | embryonic axis specification |
| BP | IEA | GO:0001658 | branching involved in ureteric bud morphogenesis |
| BP | IEA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | ISS | GO:0007267 | cell-cell signaling |
| BP | IEA | GO:0007520 | myoblast fusion |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IEP | GO:0009611 | response to wounding |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IMP | GO:0010592 | positive regulation of lamellipodium assembly |
| BP | IDA | GO:0010812 | negative regulation of cell-substrate adhesion |
| BP | IBA | GO:0016055 | Wnt signaling pathway |
| BP | IDA | GO:0016055 | Wnt signaling pathway |
| BP | TAS | GO:0016055 | Wnt signaling pathway |
| BP | IEA | GO:0021527 | spinal cord association neuron differentiation |
| BP | IEA | GO:0021536 | diencephalon development |
| BP | ISS | GO:0021551 | central nervous system morphogenesis |
| BP | ISS | GO:0021588 | cerebellum formation |
| BP | IEA | GO:0021797 | forebrain anterior/posterior pattern specification |
| BP | IEA | GO:0022004 | midbrain-hindbrain boundary maturation during brain development |
| BP | IMP | GO:0022408 | negative regulation of cell-cell adhesion |
| BP | IBA | GO:0030182 | neuron differentiation |
| BP | IEA | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| BP | IMP | GO:0030514 | negative regulation of BMP signaling pathway |
| BP | IEA | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process |
| BP | ISS | GO:0030901 | midbrain development |
| BP | IEA | GO:0031100 | animal organ regeneration |
| BP | IEA | GO:0033077 | T cell differentiation in thymus |
| BP | IEA | GO:0033278 | cell proliferation in midbrain |
| BP | IEA | GO:0036520 | astrocyte-dopaminergic neuron signaling |
| BP | IEA | GO:0042472 | inner ear morphogenesis |
| BP | IDA | GO:0042770 | signal transduction in response to DNA damage |
| BP | IDA | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway |
| BP | IMP | GO:0044336 | canonical Wnt signaling pathway involved in negative regulation of apoptotic process |
| BP | IBA | GO:0045165 | cell fate commitment |
| BP | ISS | GO:0045599 | negative regulation of fat cell differentiation |
| BP | IDA | GO:0045747 | positive regulation of Notch signaling pathway |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | ISS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0048146 | positive regulation of fibroblast proliferation |
| BP | IEA | GO:0048664 | neuron fate determination |
| BP | ISS | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | ISS | GO:0060061 | Spemann organizer formation |
| BP | IDA | GO:0060070 | canonical Wnt signaling pathway |
| BP | IMP | GO:0060070 | canonical Wnt signaling pathway |
| BP | NAS | GO:0060070 | canonical Wnt signaling pathway |
| BP | TAS | GO:0060070 | canonical Wnt signaling pathway |
| BP | TAS | GO:0060071 | Wnt signaling pathway, planar cell polarity pathway |
| BP | IMP | GO:0060348 | bone development |
| BP | IDA | GO:0061184 | positive regulation of dermatome development |
| BP | IEA | GO:0070365 | hepatocyte differentiation |
| BP | IEA | GO:0071375 | cellular response to peptide hormone stimulus |
| BP | IEA | GO:0071425 | hematopoietic stem cell proliferation |
| BP | IEA | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | IDA | GO:0090344 | negative regulation of cell aging |
| BP | IEA | GO:1903204 | negative regulation of oxidative stress-induced neuron death |
| BP | TAS | GO:1904886 | beta-catenin destruction complex disassembly |
| BP | NAS | GO:1904953 | Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation |
| BP | TAS | GO:1904953 | Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation |
| BP | TAS | GO:1904954 | canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation |
| BP | IEA | GO:1990403 | embryonic brain development |
| BP | IEA | GO:2000059 | negative regulation of ubiquitin-dependent protein catabolic process |
Gene expression in normal tissue: WNT1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in WNT1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-3238698 | WNT ligand biogenesis and trafficking |
| reactome | R-HSA-3238698 | WNT ligand biogenesis and trafficking |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373080 | Class B/2 (Secretin family receptors) |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-4086400 | PCP/CE pathway |
| reactome | R-HSA-4086400 | PCP/CE pathway |
| reactome | R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| reactome | R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| reactome | R-HSA-500792 | GPCR ligand binding |
| biocarta | gsk3pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages |
| biocarta | hespathway | segmentation clock |
| biocarta | pitx2pathway | multi-step regulation of transcription by pitx2 |
| biocarta | wntpathway | wnt signaling pathway |
| pid | cmyb_pathway | C-MYB transcription factor network |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| pid | wnt_signaling_pathway | Wnt signaling network |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa04916 | Melanogenesis - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05217 | Basal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| netpath | Pathway_Wnt | Wnt |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
| wikipathways | WP2848 | Differentiation Pathway |
| wikipathways | WP2855 | Dopaminergic Neurogenesis |
| wikipathways | WP2858 | Ectoderm Differentiation |
| wikipathways | WP3655 | Hypothetical Craniofacial Development Pathway |
| wikipathways | WP3658 | Wnt-beta-catenin Signaling Pathway in Leukemia |
| wikipathways | WP3664 | Regulation of Wnt-B-catenin Signaling by Small Molecule Compounds |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP4150 | Wnt Signaling in Kidney Disease |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP428 | Wnt Signaling Pathway |
| wikipathways | WP560 | TGF-beta Receptor Signaling |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD286 | Nsc 632839 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in WNT1
CLASSFICATION
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