DNAH8
Summary: The protein encoded by this gene is a heavy chain of an axonemal dynein involved in sperm and respiratory cilia motility. Axonemal dyneins generate force through hydrolysis of ATP and binding to microtubules. [provided by RefSeq, Jan 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| dynein axonemal heavy chain 8 | MIM:603337 | Ensembl:ENSG00000124721 | HGNC:HGNC:2952 | PA27405 | 6p21.2 |
GO terms in DNAH8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | NAS | GO:0003777 | microtubule motor activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0008569 | ATP-dependent microtubule motor activity, minus-end-directed |
| MF | IBA | GO:0045503 | dynein light chain binding |
| MF | IBA | GO:0045505 | dynein intermediate chain binding |
| MF | IBA | GO:0051959 | dynein light intermediate chain binding |
| BP | IBA | GO:0007018 | microtubule-based movement |
| BP | IBA | GO:0036158 | outer dynein arm assembly |
| BP | NAS | GO:0060285 | cilium-dependent cell motility |
| CC | NAS | GO:0005858 | axonemal dynein complex |
| CC | IEA | GO:0005874 | microtubule |
| CC | IBA | GO:0030286 | dynein complex |
| CC | IDA | GO:0030286 | dynein complex |
| CC | IBA | GO:0036157 | outer dynein arm |
Gene expression in normal tissue: DNAH8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DNAH8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05016 | Huntington,s disease - Homo sapiens (human) |
| biocarta | lis1pathway | lissencephaly gene (lis1) in neuronal migration and development |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD451 | Serdemetan | 5 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD562 | Navitoclax | 1 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD888 | Compound 44 | 7 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD494 | Neopeltolide | 4 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD779 | PRL-3 Inhibitor I | 2 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD420 | Leucascandrolide A | 9 |
| iGMDRD599 | Salermide | 7 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD152 | 179324-69-7 | 4 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD718 | Pyrvinium pamoate | 4 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD231 | Importazole | 3 |
| iGMDRD434 | BMS-536924 | 7 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD705 | Nakiterpiosin | 4 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD322 | FK 866 | 1 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD67 | PENFLURIDOL | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD584 | VER 155008 | 1 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD511 | CHEMBL399379 | 4 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 1 |
| iGMDRD85 | Ursolic acid | 6 |
| iGMDRD341 | Triacsin c | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DNAH8
CLASSFICATION
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