MKRN3
Summary: The protein encoded by this gene contains a RING (C3HC4) zinc finger motif and several C3H zinc finger motifs. This gene is intronless and imprinted, with expression only from the paternal allele. Disruption of the imprinting at this locus may contribute to Prader-Willi syndrome. An antisense RNA of unknown function has been found overlapping this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| makorin ring finger protein 3 | MIM:603856 | Ensembl:ENSG00000179455 | HGNC:HGNC:7114 | PA30833 | 15q11.2 |
GO terms in MKRN3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:1990904 | ribonucleoprotein complex |
| BP | IEA | GO:0016567 | protein ubiquitination |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0016740 | transferase activity |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: MKRN3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD505 | Pevonedistat | 4 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD782 | DC-45-A2 | 1 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD314 | Tanespimycin | 9 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD150 | RITA | 2 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD1008 | SR-II-138A | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MKRN3
CLASSFICATION
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