MYH11


Summary: The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
myosin heavy chain 11MIM:160745Ensembl:ENSG00000133392HGNC:HGNC:7569PA3136716p13.11

GO terms in MYH11


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003777microtubule motor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005516calmodulin binding
MFIEAGO:0005524ATP binding
MFIEAGO:0008017microtubule binding
MFIMPGO:0008307structural constituent of muscle
MFIEAGO:0051015actin filament binding
CCTASGO:0005829cytosol
CCTASGO:0005859muscle myosin complex
CCIEAGO:0032982myosin filament
CCIEAGO:0042470melanosome
CCHDAGO:0070062extracellular exosome
BPTASGO:0006936muscle contraction
BPISSGO:0006939smooth muscle contraction
BPIEAGO:0007018microtubule-based movement
BPISSGO:0030241skeletal muscle myosin thick filament assembly
BPIMPGO:0048251elastic fiber assembly
BPIMPGO:0048739cardiac muscle fiber development

Gene expression in normal tissue: MYH11

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MYH11


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-373755Semaphorin interactions
reactomeR-HSA-3928663EPHA-mediated growth cone collapse
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-400685Sema4D in semaphorin signaling
reactomeR-HSA-416572Sema4D induced cell migration and growth-cone collapse
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-445355Smooth Muscle Contraction
reactomeR-HSA-5625740RHO GTPases activate PKNs
reactomeR-HSA-5625900RHO GTPases activate CIT
reactomeR-HSA-5627117RHO GTPases Activate ROCKs
reactomeR-HSA-5627123RHO GTPases activate PAKs
reactomeR-HSA-5627123RHO GTPases activate PAKs
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04530Tight junction - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD945ML2143
iGMDRD123Isoevodiamine3
iGMDRD698Neratinib6
iGMDRD79Gemcitabine4
iGMDRD522ML-0301
iGMDRD322FK 8663
iGMDRD263AACOCF36
iGMDRD552AZD-17756
iGMDRD561ABT-2631
iGMDRD366PI-1033
iGMDRD329Merck603
iGMDRD662JQ-13
iGMDRD119Temsirolimus1
iGMDRD286Nsc 6328391
iGMDRD367Ro 28-16753
iGMDRD871BRD63683
iGMDRD77Itraconazole3
iGMDRD289Parthenolide6
iGMDRD5Tyrphostin AG 14786
iGMDRD251ML1626
iGMDRD121GMX17786
iGMDRD202Curcumin6
iGMDRD103SN-384
iGMDRD394BX-7953
iGMDRD466Chaetocin1
iGMDRD61Kinetin riboside4
iGMDRD152179324-69-74
iGMDRD639YK 4-2793
iGMDRD316N9-Isopropyl-olomoucine3
iGMDRD107Valdecoxib3
iGMDRD670ML 2105
iGMDRD420Leucascandrolide A3
iGMDRD889Compound 7d-cis3
iGMDRD524ISX-94
iGMDRD356PNU-746541
iGMDRD369TGX-1153
iGMDRD780PP-306
iGMDRD888Compound 443
iGMDRD188Piperlongumine3
iGMDRD187BRD98763
iGMDRD226ML0061
iGMDRD474Avrainvillamide1
iGMDRD513BML-2591
iGMDRD211(1S,3R)-RSL36
iGMDRD57Chloropentafluorobenzene3
iGMDRD351GW843682X3
iGMDRD701NVP-AUY9223
iGMDRD486Tosedostat3
iGMDRD307Manumycin A3
iGMDRD84Lovastatin acid3
iGMDRD42Vorinostat3
iGMDRD82Quiflapon1
iGMDRD505Pevonedistat3
iGMDRD300Tozasertib3
iGMDRD231Importazole3
iGMDRD481Dactolisib1
iGMDRD634SCHEMBL26080412
iGMDRD375GW-4058333
iGMDRD280CYTOCHALASIN B3
iGMDRD797ISOX DUAL3
iGMDRD201SKI II3
iGMDRD446LY 21832403
iGMDRD144NSC953973
iGMDRD772BRD47703
iGMDRD229B021
iGMDRD387CHIR-990211
iGMDRD268Cerulenin6
iGMDRD100Zebularine6
iGMDRD870BRD636103
iGMDRD441TW 371
iGMDRD782DC-45-A23
iGMDRD8024-methylfasudil1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MYH11

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