PIK3CG
Summary: Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | MIM:601232 | Ensembl:ENSG00000105851 | HGNC:HGNC:8978 | PA33311 | 7q22.3 |
GO terms in PIK3CG
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0016301 | kinase activity |
| MF | IBA | GO:0016303 | 1-phosphatidylinositol-3-kinase activity |
| MF | TAS | GO:0035004 | phosphatidylinositol 3-kinase activity |
| MF | IBA | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0046875 | ephrin receptor binding |
| MF | IBA | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| MF | IBA | GO:0052742 | phosphatidylinositol kinase activity |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | TAS | GO:0001816 | cytokine production |
| BP | TAS | GO:0002250 | adaptive immune response |
| BP | TAS | GO:0002407 | dendritic cell chemotaxis |
| BP | IEA | GO:0002675 | positive regulation of acute inflammatory response |
| BP | TAS | GO:0002679 | respiratory burst involved in defense response |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006897 | endocytosis |
| BP | TAS | GO:0006954 | inflammatory response |
| BP | IDA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| BP | TAS | GO:0010818 | T cell chemotaxis |
| BP | IEA | GO:0010897 | negative regulation of triglyceride catabolic process |
| BP | IBA | GO:0014065 | phosphatidylinositol 3-kinase signaling |
| BP | IDA | GO:0014065 | phosphatidylinositol 3-kinase signaling |
| BP | TAS | GO:0014065 | phosphatidylinositol 3-kinase signaling |
| BP | IDA | GO:0016310 | phosphorylation |
| BP | IBA | GO:0016477 | cell migration |
| BP | IBA | GO:0030168 | platelet activation |
| BP | TAS | GO:0030168 | platelet activation |
| BP | IBA | GO:0030593 | neutrophil chemotaxis |
| BP | TAS | GO:0030593 | neutrophil chemotaxis |
| BP | IEA | GO:0032252 | secretory granule localization |
| BP | TAS | GO:0033628 | regulation of cell adhesion mediated by integrin |
| BP | TAS | GO:0035747 | natural killer cell chemotaxis |
| BP | IBA | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process |
| BP | IEA | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process |
| BP | TAS | GO:0042098 | T cell proliferation |
| BP | TAS | GO:0042110 | T cell activation |
| BP | TAS | GO:0043303 | mast cell degranulation |
| BP | IDA | GO:0043406 | positive regulation of MAP kinase activity |
| BP | TAS | GO:0045087 | innate immune response |
| BP | IBA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IBA | GO:0048015 | phosphatidylinositol-mediated signaling |
| BP | IDA | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | TAS | GO:0055118 | negative regulation of cardiac muscle contraction |
| BP | TAS | GO:0070527 | platelet aggregation |
| BP | IEA | GO:0071320 | cellular response to cAMP |
| BP | TAS | GO:0072672 | neutrophil extravasation |
| BP | IEA | GO:0097284 | hepatocyte apoptotic process |
| BP | IEA | GO:1903169 | regulation of calcium ion transmembrane transport |
| BP | IEA | GO:2000270 | negative regulation of fibroblast apoptotic process |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005942 | phosphatidylinositol 3-kinase complex |
| CC | IBA | GO:0005944 | phosphatidylinositol 3-kinase complex, class IB |
| CC | IDA | GO:0005944 | phosphatidylinositol 3-kinase complex, class IB |
| CC | HDA | GO:0016020 | membrane |
| CC | IBA | GO:0016020 | membrane |
| CC | IDA | GO:0016020 | membrane |
| CC | IEA | GO:0042629 | mast cell granule |
Gene expression in normal tissue: PIK3CG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PIK3CG
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| humancyc | PWY-6352 | 3-phosphoinositide biosynthesis |
| humancyc | PWY-6371 | superpathway of inositol phosphate compounds |
| kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL5 | IL5 |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114604 | GPVI-mediated activation cascade |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483255 | PI Metabolism |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1660499 | Synthesis of PIPs at the plasma membrane |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-392451 | G beta:gamma signalling through PI3Kgamma |
| reactome | R-HSA-397795 | G-protein beta:gamma signalling |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| wikipathways | WP127 | IL-5 Signaling Pathway |
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP3676 | BDNF-TrkB Signaling |
| wikipathways | WP3678 | Amplification and Expansion of Oncogenic Pathways as Metastatic Traits |
| wikipathways | WP3680 | Association Between Physico-Chemical Features and Toxicity Associated Pathways |
| wikipathways | WP3844 | PI3K-AKT-mTOR signaling pathway and therapeutic opportunities |
| wikipathways | WP3850 | Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling |
| wikipathways | WP3872 | Regulation of Apoptosis by Parathyroid Hormone-related Protein |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP3935 | Leptin Insulin Overlap |
| wikipathways | WP3937 | Microglia Pathogen Phagocytosis Pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| wikipathways | WP581 | EPO Receptor Signaling |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| smpdb | SMP00391 | Insulin Signalling |
| smpdb | SMP00682 | Leucine Stimulation on Insulin Signaling |
| pid | cd40_pathway | CD40/CD40L signaling |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | epha_fwdpathway | EPHA forward signaling |
| pid | il8cxcr1_pathway | IL8- and CXCR1-mediated signaling events |
| pid | il8cxcr2_pathway | IL8- and CXCR2-mediated signaling events |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | pi3kcibpathway | Class IB PI3K non-lipid kinase events |
| pid | pi3kcipathway | Class I PI3K signaling events |
| pid | txa2pathway | Thromboxane A2 receptor signaling |
| pharmgkb | PA153627758 | Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA165959584 | Sorafenib Pharmacodynamics |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD213 | SMR000068650 | 6 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD137 | Indisulam | 9 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD147 | Prima-1 | 6 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD300 | Tozasertib | 5 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD607 | Ubistatin B | 6 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD341 | Triacsin c | 1 |
| iGMDRD294 | Batimastat | 3 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD247 | Blebbistatin | 6 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD451 | Serdemetan | 5 |
| iGMDRD268 | Cerulenin | 6 |
| iGMDRD690 | PRIMA-1MET | 3 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD224 | Necrostatin-1 | 5 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD100 | Zebularine | 5 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD380 | Pifithrin-alpha | 6 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD201 | SKI II | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PIK3CG
CLASSFICATION
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