ROCK2
Summary: The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Rho associated coiled-coil containing protein kinase 2 | MIM:604002 | Ensembl:ENSG00000134318 | HGNC:HGNC:10252 | PA34624 | 2p25.1 |
GO terms in ROCK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IMP | GO:0004674 | protein serine/threonine kinase activity |
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | NAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | NAS | GO:0005198 | structural molecule activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0017048 | Rho GTPase binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IMP | GO:0072518 | Rho-dependent protein serine/threonine kinase activity |
| MF | TAS | GO:0072518 | Rho-dependent protein serine/threonine kinase activity |
| BP | IMP | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0006939 | smooth muscle contraction |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IMP | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0007266 | Rho protein signal transduction |
| BP | IMP | GO:0010595 | positive regulation of endothelial cell migration |
| BP | ISS | GO:0010613 | positive regulation of cardiac muscle hypertrophy |
| BP | IMP | GO:0010628 | positive regulation of gene expression |
| BP | ISS | GO:0010628 | positive regulation of gene expression |
| BP | IEA | GO:0010825 | positive regulation of centrosome duplication |
| BP | IMP | GO:0016525 | negative regulation of angiogenesis |
| BP | IMP | GO:0018105 | peptidyl-serine phosphorylation |
| BP | ISS | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IMP | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | TAS | GO:0030155 | regulation of cell adhesion |
| BP | IGI | GO:0030866 | cortical actin cytoskeleton organization |
| BP | IMP | GO:0030866 | cortical actin cytoskeleton organization |
| BP | ISS | GO:0032723 | positive regulation of connective tissue growth factor production |
| BP | TAS | GO:0032956 | regulation of actin cytoskeleton organization |
| BP | IGI | GO:0035509 | negative regulation of myosin-light-chain-phosphatase activity |
| BP | IMP | GO:0035509 | negative regulation of myosin-light-chain-phosphatase activity |
| BP | IMP | GO:0039694 | viral RNA genome replication |
| BP | ISS | GO:0042752 | regulation of circadian rhythm |
| BP | ISS | GO:0043410 | positive regulation of MAPK cascade |
| BP | IMP | GO:0045616 | regulation of keratinocyte differentiation |
| BP | TAS | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | IEA | GO:0048511 | rhythmic process |
| BP | ISS | GO:0051246 | regulation of protein metabolic process |
| BP | IMP | GO:0051298 | centrosome duplication |
| BP | TAS | GO:0051492 | regulation of stress fiber assembly |
| BP | TAS | GO:0051893 | regulation of focal adhesion assembly |
| BP | ISS | GO:0070168 | negative regulation of biomineral tissue development |
| BP | IMP | GO:0071394 | cellular response to testosterone stimulus |
| BP | ISS | GO:0071559 | response to transforming growth factor beta |
| BP | IGI | GO:0072659 | protein localization to plasma membrane |
| BP | IMP | GO:0072659 | protein localization to plasma membrane |
| BP | ISS | GO:0090271 | positive regulation of fibroblast growth factor production |
| BP | ISS | GO:0110061 | regulation of angiotensin-activated signaling pathway |
| BP | IMP | GO:0150033 | negative regulation of protein localization to lysosome |
| BP | IMP | GO:1902004 | positive regulation of amyloid-beta formation |
| BP | ISS | GO:1902004 | positive regulation of amyloid-beta formation |
| BP | IMP | GO:1902961 | positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process |
| BP | ISS | GO:1902961 | positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process |
| BP | IMP | GO:1902966 | positive regulation of protein localization to early endosome |
| BP | IMP | GO:1902993 | positive regulation of amyloid precursor protein catabolic process |
| BP | ISS | GO:1902993 | positive regulation of amyloid precursor protein catabolic process |
| BP | IGI | GO:1903140 | regulation of establishment of endothelial barrier |
| BP | IMP | GO:1903140 | regulation of establishment of endothelial barrier |
| BP | IGI | GO:1903347 | negative regulation of bicellular tight junction assembly |
| BP | ISS | GO:1905205 | positive regulation of connective tissue replacement |
| BP | ISS | GO:1990776 | response to angiotensin |
| BP | TAS | GO:2000114 | regulation of establishment of cell polarity |
| BP | TAS | GO:2000145 | regulation of cell motility |
| CC | IEA | GO:0005634 | nucleus |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0036464 | cytoplasmic ribonucleoprotein granule |
Gene expression in normal tissue: ROCK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ROCK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | ccr3pathway | ccr3 signaling in eosinophils |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-400685 | Sema4D in semaphorin signaling |
| reactome | R-HSA-400685 | Sema4D in semaphorin signaling |
| reactome | R-HSA-416482 | G alpha (12/13) signalling events |
| reactome | R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse |
| reactome | R-HSA-416572 | Sema4D induced cell migration and growth-cone collapse |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-5627117 | RHO GTPases Activate ROCKs |
| reactome | R-HSA-5627117 | RHO GTPases Activate ROCKs |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2272 | Pathogenic Escherichia coli infection |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3680 | Association Between Physico-Chemical Features and Toxicity Associated Pathways |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP428 | Wnt Signaling Pathway |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| wikipathways | WP524 | G13 Signaling Pathway |
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | er_nongenomic_pathway | Plasma membrane estrogen receptor signaling |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| pid | plk1_pathway | PLK1 signaling events |
| pid | rhoa_pathway | RhoA signaling pathway |
| pid | thrombin_par1_pathway | PAR1-mediated thrombin signaling events |
| pid | thrombin_par4_pathway | PAR4-mediated thrombin signaling events |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) |
| kegg | hsa05131 | Shigellosis - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD486 | Tosedostat | 1 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD698 | Neratinib | 5 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD263 | AACOCF3 | 2 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD329 | Merck60 | 5 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD163 | all trans Retinoic Acid | 2 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD152 | 179324-69-7 | 4 |
| iGMDRD187 | BRD9876 | 4 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD613 | CHEMBL258148 | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD598 | QS-11 | 2 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD100 | Zebularine | 6 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD398 | Sepantronium | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ROCK2
CLASSFICATION
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