DBF4
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| DBF4 zinc finger | MIM:604281 | Ensembl:ENSG00000006634 | HGNC:HGNC:17364 | PA142672016 | 7q21.12 |
Gene Categories:
DRUGGABLE GENOMEGO terms in DBF4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003676 | nucleic acid binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008047 | enzyme activator activity |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IBA | GO:0019901 | protein kinase binding |
| MF | IBA | GO:0043539 | protein serine/threonine kinase activator activity |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0016604 | nuclear body |
| CC | IBA | GO:0031431 | Dbf4-dependent protein kinase complex |
| BP | TAS | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | TAS | GO:0006260 | DNA replication |
| BP | IEA | GO:0043085 | positive regulation of catalytic activity |
| BP | IBA | GO:0045740 | positive regulation of DNA replication |
Gene expression in normal tissue: DBF4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DBF4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP466 | DNA Replication |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-176187 | Activation of ATR in response to replication stress |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-68874 | M/G1 Transition |
| reactome | R-HSA-68962 | Activation of the pre-replicative complex |
| reactome | R-HSA-69002 | DNA Replication Pre-Initiation |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69306 | DNA Replication |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD772 | BRD4770 | 4 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD380 | Pifithrin-alpha | 5 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD247 | Blebbistatin | 5 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD224 | Necrostatin-1 | 1 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD690 | PRIMA-1MET | 2 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD148 | Pifithrin-mu | 2 |
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD607 | Ubistatin B | 4 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD532 | Olaparib | 2 |
| iGMDRD219 | Bax channel blocker | 7 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD945 | ML214 | 4 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD220 | fumonisin B1 | 1 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD231 | Importazole | 2 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD213 | SMR000068650 | 4 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD329 | Merck60 | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DBF4
CLASSFICATION
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