NGFR
Summary: Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nerve growth factor receptor | MIM:162010 | Ensembl:ENSG00000064300 | HGNC:HGNC:7809 | PA31615 | 17q21.33 |
GO terms in NGFR
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004888 | transmembrane signaling receptor activity |
| MF | IGI | GO:0005035 | death receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005516 | calmodulin binding |
| MF | IDA | GO:0015026 | coreceptor activity |
| MF | ISS | GO:0017137 | Rab GTPase binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | TAS | GO:0038023 | signaling receptor activity |
| MF | ISS | GO:0043121 | neurotrophin binding |
| MF | IBA | GO:0048406 | nerve growth factor binding |
| MF | ISS | GO:0048406 | nerve growth factor binding |
| BP | ISS | GO:0006886 | intracellular protein transport |
| BP | IMP | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | TAS | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IDA | GO:0007266 | Rho protein signal transduction |
| BP | IBA | GO:0007411 | axon guidance |
| BP | IBA | GO:0010977 | negative regulation of neuron projection development |
| BP | TAS | GO:0031293 | membrane protein intracellular domain proteolysis |
| BP | ISS | GO:0032922 | circadian regulation of gene expression |
| BP | IEA | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | ISS | GO:0042593 | glucose homeostasis |
| BP | TAS | GO:0043065 | positive regulation of apoptotic process |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | TAS | GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | TAS | GO:0048011 | neurotrophin TRK receptor signaling pathway |
| BP | TAS | GO:0050771 | negative regulation of axonogenesis |
| BP | TAS | GO:0050772 | positive regulation of axonogenesis |
| BP | IGI | GO:0051402 | neuron apoptotic process |
| BP | IDA | GO:1900182 | positive regulation of protein localization to nucleus |
| BP | IDA | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II |
| BP | IGI | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis |
| BP | IDA | GO:1904646 | cellular response to amyloid-beta |
| BP | ISS | GO:2001273 | regulation of glucose import in response to insulin stimulus |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005768 | endosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | ISS | GO:0009986 | cell surface |
| CC | NAS | GO:0016021 | integral component of membrane |
Gene expression in normal tissue: NGFR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NGFR
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04215 | Apoptosis - multiple species - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| netpath | Pathway_BDNF | BDNF |
| biocarta | cdk5pathway | phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway |
| biocarta | erkpathway | erk1/erk2 mapk signaling pathway |
| biocarta | ngfpathway | nerve growth factor pathway (ngf) |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-193634 | Axonal growth inhibition (RHOA activation) |
| reactome | R-HSA-193639 | p75NTR signals via NF-kB |
| reactome | R-HSA-193639 | p75NTR signals via NF-kB |
| reactome | R-HSA-193648 | NRAGE signals death through JNK |
| reactome | R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 |
| reactome | R-HSA-193681 | Ceramide signalling |
| reactome | R-HSA-193692 | Regulated proteolysis of p75NTR |
| reactome | R-HSA-193697 | p75NTR regulates axonogenesis |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE |
| reactome | R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE |
| reactome | R-HSA-205017 | NFG and proNGF binds to p75NTR |
| reactome | R-HSA-205025 | NADE modulates death signalling |
| reactome | R-HSA-205043 | NRIF signals cell death from the nucleus |
| reactome | R-HSA-205043 | NRIF signals cell death from the nucleus |
| reactome | R-HSA-209543 | p75NTR recruits signalling complexes |
| reactome | R-HSA-209543 | p75NTR recruits signalling complexes |
| reactome | R-HSA-209560 | NF-kB is activated and signals survival |
| reactome | R-HSA-209563 | Axonal growth stimulation |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-73887 | Death Receptor Signalling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD872 | BRD7137 | 6 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD150 | RITA | 4 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD889 | Compound 7d-cis | 6 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD137 | Indisulam | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NGFR
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.