NGFR

Summary: Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namenerve growth factor receptor
OMIM IDMIM:162010
Ensembl IDEnsembl:ENSG00000064300
HGNC IDHGNC:HGNC:7809
PHARMGKB IDPA31615
Map Location17q21.33

GO terms in NGFR


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0004888 transmembrane signaling receptor activity
MF IGI GO:0005035 death receptor activity
MF IPI GO:0005515 protein binding
MF IDA GO:0005516 calmodulin binding
MF IDA GO:0015026 coreceptor activity
MF ISS GO:0017137 Rab GTPase binding
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Gene expression in normal tissue: NGFR

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 15undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 37BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 1

Gene-drug pathway distribution

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Pathways in NGFR


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Database
Pathway ID
Pathway Des.
wikipathways WP2380 Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathways WP2431 Spinal Cord Injury
wikipathways WP3932 Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathways WP4172 PI3K-Akt Signaling Pathway
wikipathways WP4223 Ras Signaling
kegg hsa04010 MAPK signaling pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD634 SCHEMBL2608041 3
iGMDRD886 Compound 1541A 3
iGMDRD300 Tozasertib 3
iGMDRD577 BIX01294 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NGFR

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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