Summary: Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008].

nerve growth factor receptorMIM:162010Ensembl:ENSG00000064300HGNC:HGNC:7809PA3161517q21.33

GO terms in NGFR

Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004888transmembrane signaling receptor activity
MFIGIGO:0005035death receptor activity
MFIPIGO:0005515protein binding
MFIDAGO:0005516calmodulin binding
MFIDAGO:0015026coreceptor activity
MFISSGO:0017137Rab GTPase binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFTASGO:0038023signaling receptor activity
MFISSGO:0043121neurotrophin binding
MFIBAGO:0048406nerve growth factor binding
MFISSGO:0048406nerve growth factor binding
BPISSGO:0006886intracellular protein transport
BPIMPGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process
BPTASGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process
BPIDAGO:0007266Rho protein signal transduction
BPIBAGO:0007411axon guidance
BPIBAGO:0010977negative regulation of neuron projection development
BPTASGO:0031293membrane protein intracellular domain proteolysis
BPISSGO:0032922circadian regulation of gene expression
BPIEAGO:0033209tumor necrosis factor-mediated signaling pathway
BPISSGO:0042593glucose homeostasis
BPTASGO:0043065positive regulation of apoptotic process
BPTASGO:0043066negative regulation of apoptotic process
BPTASGO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPTASGO:0043281regulation of cysteine-type endopeptidase activity involved in apoptotic process
BPIBAGO:0043410positive regulation of MAPK cascade
BPTASGO:0048011neurotrophin TRK receptor signaling pathway
BPTASGO:0050771negative regulation of axonogenesis
BPTASGO:0050772positive regulation of axonogenesis
BPIGIGO:0051402neuron apoptotic process
BPIDAGO:1900182positive regulation of protein localization to nucleus
BPIDAGO:1902895positive regulation of pri-miRNA transcription by RNA polymerase II
BPIGIGO:1903588negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
BPIDAGO:1904646cellular response to amyloid-beta
BPISSGO:2001273regulation of glucose import in response to insulin stimulus
CCTASGO:0005576extracellular region
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCISSGO:0009986cell surface
CCNASGO:0016021integral component of membrane

Gene expression in normal tissue: NGFR

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NGFR

DatabasePathway IDPathway Des.
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2431Spinal Cord Injury
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4223Ras Signaling
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04215Apoptosis - multiple species - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
pidp75ntrpathwayp75(NTR)-mediated signaling
pidtrkrpathwayNeurotrophic factor-mediated Trk receptor signaling
biocartacdk5pathwayphosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway
biocartaerkpathwayerk1/erk2 mapk signaling pathway
biocartangfpathwaynerve growth factor pathway (ngf)
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-193634Axonal growth inhibition (RHOA activation)
reactomeR-HSA-193639p75NTR signals via NF-kB
reactomeR-HSA-193639p75NTR signals via NF-kB
reactomeR-HSA-193648NRAGE signals death through JNK
reactomeR-HSA-193670p75NTR negatively regulates cell cycle via SC1
reactomeR-HSA-193681Ceramide signalling
reactomeR-HSA-193692Regulated proteolysis of p75NTR
reactomeR-HSA-193697p75NTR regulates axonogenesis
reactomeR-HSA-193704p75 NTR receptor-mediated signalling
reactomeR-HSA-193704p75 NTR receptor-mediated signalling
reactomeR-HSA-204998Cell death signalling via NRAGE, NRIF and NADE
reactomeR-HSA-204998Cell death signalling via NRAGE, NRIF and NADE
reactomeR-HSA-205017NFG and proNGF binds to p75NTR
reactomeR-HSA-205025NADE modulates death signalling
reactomeR-HSA-205043NRIF signals cell death from the nucleus
reactomeR-HSA-205043NRIF signals cell death from the nucleus
reactomeR-HSA-209543p75NTR recruits signalling complexes
reactomeR-HSA-209543p75NTR recruits signalling complexes
reactomeR-HSA-209560NF-kB is activated and signals survival
reactomeR-HSA-209563Axonal growth stimulation
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-73887Death Receptor Signalling

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD886Compound 1541A3
iGMDRD341Triacsin c3
iGMDRD446LY 21832401
iGMDRD286Nsc 6328393
iGMDRD889Compound 7d-cis6

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NGFR