GOLPH3


Summary: The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a peripheral membrane protein of the Golgi stack and may have a regulatory role in Golgi trafficking. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
golgi phosphoprotein 3MIM:612207Ensembl:ENSG00000113384HGNC:HGNC:15452PA288125p13.3

GO terms in GOLPH3


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFIPIGO:0019899enzyme binding
MFIBAGO:0070273phosphatidylinositol-4-phosphate binding
MFIDAGO:0070273phosphatidylinositol-4-phosphate binding
BPIBAGO:0006890retrograde vesicle-mediated transport, Golgi to ER
BPIBAGO:0007030Golgi organization
BPIMPGO:0007030Golgi organization
BPIMPGO:0008283cell proliferation
BPIMPGO:0009101glycoprotein biosynthetic process
BPIMPGO:0009306protein secretion
BPIMPGO:0010467gene expression
BPIDAGO:0010821regulation of mitochondrion organization
BPIMPGO:0016477cell migration
BPIMPGO:0030032lamellipodium assembly
BPIMPGO:0032008positive regulation of TOR signaling
BPIBAGO:0043001Golgi to plasma membrane protein transport
BPIMPGO:0043001Golgi to plasma membrane protein transport
BPIMPGO:0043066negative regulation of apoptotic process
BPIMPGO:0045053protein retention in Golgi apparatus
BPIBAGO:0048194Golgi vesicle budding
BPIMPGO:0048194Golgi vesicle budding
BPIMPGO:0050714positive regulation of protein secretion
BPIMPGO:0050901leukocyte tethering or rolling
BPIMPGO:0060352cell adhesion molecule production
BPIMPGO:0090161Golgi ribbon formation
BPIMPGO:0090164asymmetric Golgi ribbon formation
CCIDAGO:0005739mitochondrion
CCIEAGO:0005758mitochondrial intermembrane space
CCIEAGO:0005768endosome
CCIDAGO:0005794Golgi apparatus
CCIMPGO:0005794Golgi apparatus
CCIBAGO:0005802trans-Golgi network
CCIDAGO:0005802trans-Golgi network
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCIEAGO:0005886plasma membrane
CCIBAGO:0031985Golgi cisterna
CCIDAGO:0031985Golgi cisterna
CCIEAGO:0032580Golgi cisterna membrane
CCIDAGO:0043231intracellular membrane-bounded organelle

Gene expression in normal tissue: GOLPH3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GOLPH3


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD560MK-22061
iGMDRD424Tamatinib1
iGMDRD387CHIR-990212
iGMDRD126Tipifarnib1
iGMDRD210AC556491
iGMDRD177Teniposide1
iGMDRD61Kinetin riboside4
iGMDRD885Compound 1105
iGMDRD870BRD636102
iGMDRD782DC-45-A22
iGMDRD158NSC1415403
iGMDRD474Avrainvillamide2
iGMDRD524ISX-95
iGMDRD886Compound 1541A2
iGMDRD505Pevonedistat2
iGMDRD60Quinoclamine2
iGMDRD369TGX-1152
iGMDRD506Fedratinib6
iGMDRD329Merck601
iGMDRD399Selumetinib2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GOLPH3

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