GOLPH3
Summary: The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a peripheral membrane protein of the Golgi stack and may have a regulatory role in Golgi trafficking. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of these variants has not been determined. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| golgi phosphoprotein 3 | MIM:612207 | Ensembl:ENSG00000113384 | HGNC:HGNC:15452 | PA28812 | 5p13.3 |
GO terms in GOLPH3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IBA | GO:0070273 | phosphatidylinositol-4-phosphate binding |
| MF | IDA | GO:0070273 | phosphatidylinositol-4-phosphate binding |
| BP | IBA | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER |
| BP | IBA | GO:0007030 | Golgi organization |
| BP | IMP | GO:0007030 | Golgi organization |
| BP | IMP | GO:0008283 | cell proliferation |
| BP | IMP | GO:0009101 | glycoprotein biosynthetic process |
| BP | IMP | GO:0009306 | protein secretion |
| BP | IMP | GO:0010467 | gene expression |
| BP | IDA | GO:0010821 | regulation of mitochondrion organization |
| BP | IMP | GO:0016477 | cell migration |
| BP | IMP | GO:0030032 | lamellipodium assembly |
| BP | IMP | GO:0032008 | positive regulation of TOR signaling |
| BP | IBA | GO:0043001 | Golgi to plasma membrane protein transport |
| BP | IMP | GO:0043001 | Golgi to plasma membrane protein transport |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0045053 | protein retention in Golgi apparatus |
| BP | IBA | GO:0048194 | Golgi vesicle budding |
| BP | IMP | GO:0048194 | Golgi vesicle budding |
| BP | IMP | GO:0050714 | positive regulation of protein secretion |
| BP | IMP | GO:0050901 | leukocyte tethering or rolling |
| BP | IMP | GO:0060352 | cell adhesion molecule production |
| BP | IMP | GO:0090161 | Golgi ribbon formation |
| BP | IMP | GO:0090164 | asymmetric Golgi ribbon formation |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IEA | GO:0005758 | mitochondrial intermembrane space |
| CC | IEA | GO:0005768 | endosome |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IMP | GO:0005794 | Golgi apparatus |
| CC | IBA | GO:0005802 | trans-Golgi network |
| CC | IDA | GO:0005802 | trans-Golgi network |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IBA | GO:0031985 | Golgi cisterna |
| CC | IDA | GO:0031985 | Golgi cisterna |
| CC | IEA | GO:0032580 | Golgi cisterna membrane |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
Gene expression in normal tissue: GOLPH3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GOLPH3
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD560 | MK-2206 | 1 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD885 | Compound 110 | 5 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD524 | ISX-9 | 5 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD399 | Selumetinib | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GOLPH3
CLASSFICATION
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