BUB1
Summary: This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BUB1 mitotic checkpoint serine/threonine kinase | MIM:602452 | Ensembl:ENSG00000169679 | HGNC:HGNC:1148 | PA81 | 2q13 |
GO terms in BUB1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004672 | protein kinase activity |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IDA | GO:0007063 | regulation of sister chromatid cohesion |
| BP | TAS | GO:0007093 | mitotic cell cycle checkpoint |
| BP | IBA | GO:0007094 | mitotic spindle assembly checkpoint |
| BP | IEA | GO:0008283 | cell proliferation |
| BP | IEA | GO:0016032 | viral process |
| BP | IEA | GO:0051301 | cell division |
| BP | IBA | GO:0051754 | meiotic sister chromatid cohesion, centromeric |
| BP | IMP | GO:0051983 | regulation of chromosome segregation |
| CC | IDA | GO:0000776 | kinetochore |
| CC | IDA | GO:0000777 | condensed chromosome kinetochore |
| CC | IBA | GO:0000778 | condensed nuclear chromosome kinetochore |
| CC | IDA | GO:0000942 | condensed nuclear chromosome outer kinetochore |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0016020 | membrane |
Gene expression in normal tissue: BUB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BUB1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | aurora_b_pathway | Aurora B signaling |
| pid | p73pathway | p73 transcription factor network |
| pid | plk1_pathway | PLK1 signaling events |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP3878 | ATM Signaling Network in Development and Disease |
| wikipathways | WP4240 | Regulation of sister chromatid separation at the metaphase-anaphase transition |
| reactome | R-HSA-141424 | Amplification of signal from the kinetochores |
| reactome | R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2500257 | Resolution of Sister Chromatid Cohesion |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69618 | Mitotic Spindle Checkpoint |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD780 | PP-30 | 3 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD513 | BML-259 | 4 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD341 | Triacsin c | 1 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD248 | BRD4354 | 2 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD583 | LDN 193189 | 1 |
| iGMDRD779 | PRL-3 Inhibitor I | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BUB1
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