TCF21
Summary: TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| transcription factor 21 | MIM:603306 | Ensembl:ENSG00000118526 | HGNC:HGNC:11632 | PA36387 | 6q23.2 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in TCF21
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISS | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IEA | GO:0042826 | histone deacetylase binding |
| MF | IPI | GO:0043425 | bHLH transcription factor binding |
| MF | ISS | GO:0046983 | protein dimerization activity |
| MF | ISS | GO:0050681 | androgen receptor binding |
| MF | ISS | GO:0070888 | E-box binding |
| CC | IDA | GO:0005634 | nucleus |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0001657 | ureteric bud development |
| BP | ISS | GO:0001658 | branching involved in ureteric bud morphogenesis |
| BP | ISS | GO:0001763 | morphogenesis of a branching structure |
| BP | ISS | GO:0001822 | kidney development |
| BP | ISS | GO:0001944 | vasculature development |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | ISS | GO:0007530 | sex determination |
| BP | ISS | GO:0014707 | branchiomeric skeletal muscle development |
| BP | ISS | GO:0030855 | epithelial cell differentiation |
| BP | ISS | GO:0032835 | glomerulus development |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0048286 | lung alveolus development |
| BP | ISS | GO:0048536 | spleen development |
| BP | ISS | GO:0048557 | embryonic digestive tract morphogenesis |
| BP | ISS | GO:0048608 | reproductive structure development |
| BP | ISS | GO:0048732 | gland development |
| BP | ISS | GO:0060008 | Sertoli cell differentiation |
| BP | ISS | GO:0060021 | roof of mouth development |
| BP | ISS | GO:0060425 | lung morphogenesis |
| BP | ISS | GO:0060426 | lung vasculature development |
| BP | ISS | GO:0060435 | bronchiole development |
| BP | ISS | GO:0060539 | diaphragm development |
| BP | ISS | GO:0060541 | respiratory system development |
| BP | ISS | GO:0060766 | negative regulation of androgen receptor signaling pathway |
| BP | ISS | GO:0072162 | metanephric mesenchymal cell differentiation |
| BP | ISS | GO:0072277 | metanephric glomerular capillary formation |
Gene expression in normal tissue: TCF21
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TCF21
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD474 | Avrainvillamide | 5 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD144 | NSC95397 | 9 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD60 | Quinoclamine | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TCF21
CLASSFICATION
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