MTCL1
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| microtubule crosslinking factor 1 | MIM:615766 | Ensembl:ENSG00000168502 | HGNC:HGNC:29121 | PA128394616 | 18p11.22 |
GO terms in MTCL1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0001578 | microtubule bundle formation |
| BP | ISS | GO:0001578 | microtubule bundle formation |
| BP | IEA | GO:0010506 | regulation of autophagy |
| BP | IBA | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity |
| BP | ISS | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity |
| BP | ISS | GO:0090314 | positive regulation of protein targeting to membrane |
| BP | ISS | GO:2000576 | positive regulation of microtubule motor activity |
| CC | IBA | GO:0000922 | spindle pole |
| CC | IDA | GO:0000922 | spindle pole |
| CC | IEA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005856 | cytoskeleton |
| CC | IEA | GO:0016324 | apical plasma membrane |
| CC | IBA | GO:0016327 | apicolateral plasma membrane |
| CC | ISS | GO:0016327 | apicolateral plasma membrane |
| CC | IBA | GO:0016328 | lateral plasma membrane |
| CC | ISS | GO:0016328 | lateral plasma membrane |
| CC | IBA | GO:0030496 | midbody |
| CC | IDA | GO:0030496 | midbody |
| CC | IBA | GO:0097427 | microtubule bundle |
| CC | ISS | GO:0097427 | microtubule bundle |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0008017 | microtubule binding |
| MF | IDA | GO:0008017 | microtubule binding |
| MF | ISS | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: MTCL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MTCL1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD23 | Gossypol | 5 |
| iGMDRD598 | QS-11 | 2 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD730 | Kahalalide F | 2 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD484 | Pluripotin | 2 |
| iGMDRD427 | ABT737 | 4 |
| iGMDRD599 | Salermide | 4 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD433 | Lexibulin | 1 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD679 | Bistramide A | 4 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD446 | LY 2183240 | 5 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD300 | Tozasertib | 6 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD882 | CIL41 | 1 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD607 | Ubistatin B | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD330 | BRD4132 | 4 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD237 | ABT-751 | 2 |
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in MTCL1

